Pre_GI: BLASTP Hits

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Query: NC_012579:72715:84657 Bacillus anthracis str. CDC 684 plasmid pX01, complete sequence

Start: 84657, End: 85970, Length: 1314

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012656:67949:8461384613859261314Bacillus anthracis str. A0248 plasmid pXO1, complete sequencepXO1-700914
NC_014331:57769:8464284642859551314Bacillus cereus biovar anthracis str. CI plasmid pCI-XO1, completeribosomal protein L7Ae family protein0914
NC_007322:57710:8434984349856621314Bacillus anthracis str. 'Ames Ancestor' plasmid pXO1, completehypothetical protein0914
NC_012473:46000:7172771727730401314Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequencehypothetical protein0886
NC_017203:73952:1006011006011019141314Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT281,hypothetical protein0876
NC_011777:100631:1006311006311019471317Bacillus cereus AH820 plasmid pAH820_272, complete sequencehypothetical protein0766
NC_005707:12735:319663196632889924Bacillus cereus ATCC 10987 plasmid pBc10987, complete sequencehypothetical protein, pXO1-70, interruption-C1e-130466
NC_005707:12735:355923559236122531Bacillus cereus ATCC 10987 plasmid pBc10987, complete sequencehypothetical protein, pXO1-70, interruption-N3e-80299
NC_011775:156673:1755561755561768571302Bacillus cereus G9842 plasmid pG9842_209, complete sequenceputative DNA primase3e-67255
NC_007103:198500:2130562130562143721317Bacillus cereus E33L plasmid pE33L466, complete sequencepossible DNA primase7e-63241
NC_007644:362000:363360363360364346987Moorella thermoacetica ATCC 39073, complete genomeTOPRIM3e-1893.2
NC_013216:1442044:144204414420441443015972Desulfotomaculum acetoxidans DSM 771, complete genomehypothetical protein1e-0964.7
NC_012654:92487:1121791121791136031425Clostridium botulinum Ba4 str. 657 plasmid pCLJ, complete sequenceDNA primase5e-0962.8
NC_009253:1031799:1040355104035510413561002Desulfotomaculum reducens MI-1 chromosome, complete genomeTOPRIM2e-0654.7