Pre_GI: BLASTP Hits

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Query: NC_012579:72715:78248 Bacillus anthracis str. CDC 684 plasmid pX01, complete sequence

Start: 78248, End: 78856, Length: 609

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012656:67949:782047820478812609Bacillus anthracis str. A0248 plasmid pXO1, complete sequencehypothetical protein6e-113406
NC_007322:57710:779437794378548606Bacillus anthracis str. 'Ames Ancestor' plasmid pXO1, completehypothetical protein4e-112403
NC_014331:57769:782387823878843606Bacillus cereus biovar anthracis str. CI plasmid pCI-XO1, completemembrane protein8e-111399
NC_012473:46000:628076280763415609Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequencehypothetical protein3e-103374
NC_014331:57769:8003080030819551926Bacillus cereus biovar anthracis str. CI plasmid pCI-XO1, completeputative metal-binding/nucleic acid-binding protein5e-1580.9
NC_012473:46000:6460064600665251926Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequencehypothetical protein1e-1479.3
NC_007322:57710:813808138081664285Bacillus anthracis str. 'Ames Ancestor' plasmid pXO1, completehypothetical protein5e-0857.8