Pre_GI: BLASTP Hits

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Query: NC_012579:72715:72715 Bacillus anthracis str. CDC 684 plasmid pX01, complete sequence

Start: 72715, End: 73575, Length: 861

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014331:57769:724337243373293861Bacillus cereus biovar anthracis str. CI plasmid pCI-XO1, completehypothetical protein2e-145514
NC_017203:73952:115003115003115863861Bacillus thuringiensis serovar chinensis CT-43 plasmid pCT281,hypothetical protein1e-143508
NC_012473:46000:569985699857858861Bacillus cereus 03BB102 plasmid p03BB102_179, complete sequenceFlp pilus assembly protein CpaB3e-142504
NC_012656:67949:726727267273277606Bacillus anthracis str. A0248 plasmid pXO1, complete sequence6e-96350
NC_007322:57710:724087240873013606Bacillus anthracis str. 'Ames Ancestor' plasmid pXO1, completehypothetical protein6e-96350
NC_011775:185409:191954191954192865912Bacillus cereus G9842 plasmid pG9842_209, complete sequencehypothetical secreted protein2e-41169