Pre_GI: BLASTP Hits

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Query: NC_012579:1:14584 Bacillus anthracis str. CDC 684 plasmid pX01, complete sequence

Start: 14584, End: 15288, Length: 705

Host Lineage: Bacillus anthracis; Bacillus; Bacillaceae; Bacillales; Firmicutes; Bacteria

General Information: This organism was the first to be shown to cause disease by Dr. Robert Koch, leading to the formulation of Koch's postulates, which were verified by Dr. Louis Pasteur (the organism, isolated from sick animals, was grown in the laboratory and then used to infect healthy animals and make them sick). This organism was also the first for which an attenuated strain was developed as a vaccine. Herbivorous animals become infected with the organism when they ingest spores from the soil whereas humans become infected when they come into contact with a contaminated animal. Anthrax is not transmitted due to person-to-person contact. The three forms of the disease reflect the sites of infection which include cutaneous (skin), pulmonary (lung), and intestinal. Pulmonary and intestinal infections are often fatal if left untreated. Spores are taken up by macrophages and become internalized into phagolysozomes (membranous compartment) whereupon germination initiates. Bacteria are released into the bloodstream once the infected macrophage lyses whereupon they rapidly multiply, spreading throughout the circulatory and lymphatic systems, a process that results in septic shock, respiratory distress and organ failure. The spores of this pathogen have been used as a terror weapon.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_007322:1:143711437115063693Bacillus anthracis str. 'Ames Ancestor' plasmid pXO1, completehypothetical protein1e-109395
NC_012656:1:146231462315327705Bacillus anthracis str. A0248 plasmid pXO1, complete sequencehypothetical protein1e-111402
NC_014331:1:143531435315057705Bacillus cereus biovar anthracis str. CI plasmid pCI-XO1, completehypothetical protein1e-111402