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Query: NC_012563:811993:821769 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 821769, End: 824489, Length: 2721

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015164:4053765:4051472405147240537842313Bacteroides salanitronis DSM 18170 chromosome, complete genomehypothetical protein4e-24114
NC_014836:497350:5063815063815085042124Desulfurispirillum indicum S5 chromosome, complete genomehypothetical protein5e-24114
NC_013421:1819036:1833269183326918356682400Pectobacterium wasabiae WPP163, complete genomehypothetical protein6e-24113
NC_012779:1939747:1959673195967319620722400Edwardsiella ictaluri 93-146, complete genomehypothetical protein3e-21104
NC_012912:4428111:4434572443457244371362565Dickeya zeae Ech1591, complete genomehypothetical protein1e-20102
NC_014842:19411:2531825318277172400Pantoea sp. At-9b plasmid pPAT9B05, complete sequencehypothetical protein1e-20102
NC_020209:3874844:3885698388569838882232526Pseudomonas poae RE*1-1-14, complete genomehypothetical protein3e-20101
NC_004547:2285092:2294424229442422970002577Erwinia carotovora subsp. atroseptica SCRI1043, complete genomehypothetical protein1e-1999
NC_013716:1918664:1925909192590919284792571Citrobacter rodentium ICC168, complete genomehypothetical protein6e-1687
NC_015663:3586836:3598450359845036011522703Enterobacter aerogenes KCTC 2190 chromosome, complete genomehypothetical protein3e-1584.7
NC_014033:2080818:2099718209971821022582541Prevotella ruminicola 23 chromosome, complete genomehypothetical protein6e-1480.5
NC_012559:1685812:1693392169339216959112520Laribacter hongkongensis HLHK9, complete genomehypothetical protein4e-1377.8
NC_014926:165312:1731011731011753082208Thermovibrio ammonificans HB-1 chromosome, complete genomehypothetical protein2e-1275.1