Pre_GI: BLASTP Hits

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Query: NC_012563:4101000:4121503 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 4121503, End: 4121580, Length: 78

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:3939328:39591573959157395923377Clostridium botulinum F str. 230613 chromosome, complete genometRNA-Val7e-0752.8
NC_010516:3903867:39243363924336392441378Clostridium botulinum B1 str. Okra, complete genometRNA-Val7e-0752.8
NC_010520:3938490:39589783958978395905578Clostridium botulinum A3 str. Loch Maree, complete genometRNA-Val7e-0752.8
NC_012563:4101000:41211634121163412124078Clostridium botulinum A2 str. Kyoto, complete genometRNA-Val7e-0752.8
NC_010520:3938490:39586383958638395871578Clostridium botulinum A3 str. Loch Maree, complete genometRNA-Val7e-0752.8
NC_010516:3903867:39239963923996392407378Clostridium botulinum B1 str. Okra, complete genometRNA-Val7e-0752.8
NC_010520:3938490:39583293958329395840678Clostridium botulinum A3 str. Loch Maree, complete genometRNA-Val7e-0752.8
NC_010516:3903867:39236873923687392376478Clostridium botulinum B1 str. Okra, complete genometRNA-Val7e-0752.8
NC_012563:4101000:41208544120854412093178Clostridium botulinum A2 str. Kyoto, complete genometRNA-Val7e-0752.8
NC_009699:3940984:39611213961121396119878Clostridium botulinum F str. Langeland chromosome, complete genometRNA-Val7e-0752.8
NC_009699:3940984:39614613961461396153878Clostridium botulinum F str. Langeland chromosome, complete genometRNA-Val7e-0752.8
NC_012658:3923546:39433893943389394346678Clostridium botulinum Ba4 str. 657 chromosome, complete genometRNA-Val7e-0752.8
NC_012658:3923546:39436983943698394377578Clostridium botulinum Ba4 str. 657 chromosome, complete genometRNA-Val7e-0752.8
NC_012658:3923546:39440383944038394411578Clostridium botulinum Ba4 str. 657 chromosome, complete genometRNA-Val7e-0752.8
NC_010723:485874:50150050150050157778Clostridium botulinum E3 str. Alaska E43, complete genometRNA-Val4e-0650.1
NC_010723:485874:50177150177150184878Clostridium botulinum E3 str. Alaska E43, complete genometRNA-Val4e-0650.1