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Query: NC_012563:4101000:4121257 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 4121257, End: 4121333, Length: 77

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012658:3923546:39437923943792394386877Clostridium botulinum Ba4 str. 657 chromosome, complete genometRNA-Glu4e-0753.5
NC_009699:3940984:39612153961215396129177Clostridium botulinum F str. Langeland chromosome, complete genometRNA-Glu4e-0753.5
NC_010516:3903867:39240903924090392416677Clostridium botulinum B1 str. Okra, complete genometRNA-Glu4e-0753.5
NC_010520:3938490:39587323958732395880877Clostridium botulinum A3 str. Loch Maree, complete genometRNA-Glu4e-0753.5
NC_012658:3923546:39434823943482394355877Clostridium botulinum Ba4 str. 657 chromosome, complete genometRNA-Glu3e-0650.4
NC_010516:3903867:39237803923780392385677Clostridium botulinum B1 str. Okra, complete genometRNA-Glu3e-0650.4
NC_012563:4101000:41209474120947412102377Clostridium botulinum A2 str. Kyoto, complete genometRNA-Glu3e-0650.4
NC_010520:3938490:39584223958422395849877Clostridium botulinum A3 str. Loch Maree, complete genometRNA-Glu3e-0650.4