Pre_GI: BLASTP Hits

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Query: NC_012563:4101000:4119620 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 4119620, End: 4120597, Length: 978

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012658:3923546:394215639421563943133978Clostridium botulinum Ba4 str. 657 chromosome, complete genomeDNA replication protein DnaC1e-165582
NC_010516:3903867:392245439224543923431978Clostridium botulinum B1 str. Okra, complete genomeputative DNA replication protein DnaC1e-165582
NC_010520:3938490:395709639570963958073978Clostridium botulinum A3 str. Loch Maree, complete genomeputative DNA replication protein DnaC1e-165582
NC_009495:3832500:385110138511013852078978Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeDNA replication protein DnaC2e-165581
NC_009697:3809044:382763538276353828612978Clostridium botulinum A str. ATCC 19397 chromosome, completeDNA replication protein DnaC2e-165581
NC_009698:3706154:372474537247453725722978Clostridium botulinum A str. Hall chromosome, complete genomeDNA replication protein DnaC2e-165581
NC_017297:3939328:395792239579223958899978Clostridium botulinum F str. 230613 chromosome, complete genomeputative DNA replication protein DnaC4e-165580
NC_009699:3940984:395957939595793960556978Clostridium botulinum F str. Langeland chromosome, complete genomeDNA replication protein DnaC4e-165580
NC_004557:81362:827778277783766990Clostridium tetani E88, complete genomeDNA replication protein DnaC8e-98357
NC_008593:37456:379463794638938993Clostridium novyi NT, complete genomeDNA replication protein DnaC, putative2e-93342
NC_021182:4882494:490745349074534908436984Clostridium pasteurianum BC1, complete genomeDNA replication protein3e-92338
NC_015425:34861:372053720538164960Clostridium botulinum BKT015925 chromosome, complete genomeDNA replication protein DnaC5e-90331
NC_014328:4546390:456307645630764564062987Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative DNA replication protein DnaC8e-90330
NC_003030:3763054:378811137881113789100990Clostridium acetobutylicum ATCC 824, complete genomeDNA replication protein DnaC7e-88323
NC_015687:3766000:378969437896943790683990Clostridium acetobutylicum DSM 1731 chromosome, complete genomeDNA replication protein DnaC7e-88323
NC_017295:3762622:378746937874693788452984Clostridium acetobutylicum EA 2018 chromosome, complete genomeDNA replication protein DnaC8e-88323
NC_014624:140000:156537156537157508972Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein7e-54211
NC_014392:1935130:1954240195424019552681029Caldicellulosiruptor obsidiansis OB47 chromosome, complete genomeAAA ATPase4e-33142
NC_014652:757381:7715567715567725961041Caldicellulosiruptor hydrothermalis 108 chromosome, completeaaa atpase6e-33141
NC_006177:3457637:3479451347945134804761026Symbiobacterium thermophilum IAM 14863, complete genomeDNA replication protein DnaC1e-25117
NC_018870:1506918:151971615197161520501786Thermacetogenium phaeum DSM 12270 chromosome, complete genomeIstB-like ATP-binding protein9e-1271.2