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Query: NC_012563:4101000:4101027 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 4101027, End: 4101512, Length: 486

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010516:3903867:390386739038673904352486Clostridium botulinum B1 str. Okra, complete genomehypothetical protein9e-88322
NC_012658:3923546:392354639235463924031486Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein2e-87320
NC_009698:3706154:370615437061543706639486Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein4e-87319
NC_009697:3809044:380904438090443809529486Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein4e-87319
NC_009495:3832500:383251038325103832995486Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein4e-87319
NC_010520:3938490:393849039384903938975486Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein7e-87318
NC_009699:3940984:394098439409843941472489Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein2e-86317
NC_017297:3939328:393932839393283939816489Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein2e-86317
NC_004557:81362:994849948499975492Clostridium tetani E88, complete genomehypothetical protein8e-54209
NC_014328:4546390:454639045463904546854465Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein5e-45179
NC_004722:4496000:451786945178694518360492Bacillus cereus ATCC 14579, complete genomehypothetical Cytosolic Protein1e-35148
NC_011772:4487378:450351045035104504001492Bacillus cereus G9842, complete genomehypothetical protein1e-35148
NC_003909:4333097:435603043560304356521492Bacillus cereus ATCC 10987, complete genomehypothetical protein4e-35146
NC_014915:2963500:299383329938332994387555Geobacillus sp. Y412MC52 chromosome, complete genomedUTPase1e-28125
NC_013411:597235:609548609548610102555Geobacillus sp. Y412MC61, complete genomedUTPase1e-28125
NC_014639:1538782:158633915863391586893555Bacillus atrophaeus 1942 chromosome, complete genomehypothetical protein3e-26117
CP002207:1538782:158633915863391586893555Bacillus atrophaeus 1942, complete genomehypothetical protein3e-26117
UCMB5137:120656:127504127504128061558Bacillus atrophaeus UCMB-5137hypothetical protein3e-26117
NC_012914:1851102:187470518747051875202498Paenibacillus sp. JDR-2, complete genomedUTPase4e-25113
NC_015660:739040:751768751768752382615Geobacillus thermoglucosidasius C56-YS93 chromosome, completedUTPase2e-24111
NC_020272:1311932:133203213320321332631600Bacillus amyloliquefaciens IT-45, complete genomehypothetical protein2e-23108
NC_014551:576000:588621588621589220600Bacillus amyloliquefaciens DSM 7, complete genomehypothetical protein7e-23106
NC_017208:1831918:185407518540751854614540Bacillus thuringiensis serovar chinensis CT-43 chromosome, completePhage protein2e-1995.1
NC_004722:1804788:182346018234601823795336Bacillus cereus ATCC 14579, complete genomePhage protein6e-0960.1
NC_014014:359217:376898376898377395498Mycoplasma crocodyli MP145 chromosome, complete genomedUTP diphosphatase8e-0959.7