Pre_GI: BLASTP Hits

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Query: NC_012563:3921859:3929826 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 3929826, End: 3930356, Length: 531

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012658:3744000:375283837528383753368531Clostridium botulinum Ba4 str. 657 chromosome, complete genome3e-88323
NC_009698:3526359:353502035350203535550531Clostridium botulinum A str. Hall chromosome, complete genome2-oxoglutarate ferredoxin oxidoreductase subunit gamma3e-88323
NC_010516:3724312:373297537329753733505531Clostridium botulinum B1 str. Okra, complete genome2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family3e-88323
NC_017297:3752000:376336837633683763898531Clostridium botulinum F str. 230613 chromosome, complete genome2-oxoglutarate ferredoxin oxidoreductase subunit gamma6e-88322
NC_010520:3753875:376248937624893763019531Clostridium botulinum A3 str. Loch Maree, complete genome2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family5e-87319
NC_015958:2206032:222869722286972229254558Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase subunit gamma7e-42169
NC_014538:1942500:194811319481131948670558Thermoanaerobacter sp. X513 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase subunit gamma8e-41166
NC_014632:11925:261012610126643543Ilyobacter polytropus DSM 2926 chromosome, complete genome2-oxoglutarate ferredoxin oxidoreductase subunit gamma2e-37155
NC_015555:386000:395670395670396221552Thermoanaerobacterium xylanolyticum LX-11 chromosome, completepyruvate/ketoisovalerate oxidoreductase, gamma subunit2e-37155
NC_017243:3093393:311501531150153115569555Brachyspira intermedia PWS/A chromosome, complete genomepyruvate ferredoxin oxireductase2e-37154
NC_016751:142237:154973154973155521549Marinitoga piezophila KA3 chromosome, complete genome2-oxoacid:acceptor oxidoreductase subunit gamma, pyruvate/2-ketoisovalerate family3e-37154
NC_016629:1175828:119661211966121197154543Desulfovibrio africanus str. Walvis Bay chromosome, completepyruvate/ketoisovalerate oxidoreductase6e-37153
NC_013316:120759:156553156553157110558Clostridium difficile R20291, complete genomeputative subunit of oxidoreductase1e-36152
NC_009089:117980:161043161043161600558Clostridium difficile 630, complete genomeputative subunit of oxidoreductase1e-36152
NC_011769:2542000:254915525491552549697543Desulfovibrio vulgaris str. 'Miyazaki F', complete genomepyruvate ferredoxin/flavodoxin oxidoreductase8e-37152
NC_014614:1309203:131525913152591315789531Clostridium sticklandii, complete genomePyruvate ferredoxin/flavodoxin oxidoreductase3e-35147
NC_014652:1651671:167217316721731672712540Caldicellulosiruptor hydrothermalis 108 chromosome, completepyruvate/ketoisovalerate oxidoreductase, catalytic domain protein1e-34145
NC_010003:1577934:159112515911251591667543Petrotoga mobilis SJ95, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit5e-33140
NC_009616:99647:104889104889105425537Thermosipho melanesiensis BI429 chromosome, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase5e-32137
NC_011653:331986:338461338461339000540Thermosipho africanus TCF52B, complete genome2-oxoglutarate oxidoreductase, gamma subunit9e-32135
NC_009615:1601170:161744316174431617985543Parabacteroides distasonis ATCC 8503 chromosome, complete genomeketoisovalerate oxidoreductase subunit vorA2e-31134
NC_015499:352934:369855369855370397543Thermodesulfobium narugense DSM 14796 chromosome, complete genomePyruvate/ketoisovalerate oxidoreductase7e-28123
NC_007517:1468719:147064114706411471195555Geobacter metallireducens GS-15, complete genomePyruvate ferredoxin/flavodoxin oxidoreductase2e-24111
NC_009515:307800:3141933141933156531461Methanobrevibacter smithii ATCC 35061, complete genome2-oxoisovalerate ferredoxin oxidoreductase, beta subunit2e-23108
NC_002939:2008304:203715720371572037696540Geobacter sulfurreducens PCA, complete genomeketo/oxoacid ferredoxin oxidoreductase, gamma subunit1e-22105
NC_013156:728397:736112736112736654543Methanocaldococcus fervens AG86, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit2e-1891.7
NC_000909:467607:472377472377472940564Methanocaldococcus jannaschii DSM 2661, complete genomeindolepyruvate ferredoxin oxidoreductase9e-1889.7
NC_007517:1515493:152760515276051528153549Geobacter metallireducens GS-15, complete genomePyruvate ferredoxin/flavodoxin oxidoreductase9e-1889.7
NC_013407:1205747:122819812281981228740543Methanocaldococcus vulcanius M7, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit1e-1789.4
NC_014972:1510914:153784915378491538451603Desulfobulbus propionicus DSM 2032 chromosome, complete genome2-oxoglutarate ferredoxin oxidoreductase subunit gamma7e-1786.7
NC_014011:527681:544088544088544654567Aminobacterium colombiense DSM 12261 chromosome, complete genomePyruvate/ketoisovalerate oxidoreductase2e-1685.5
NC_002939:1601706:161215316121531612701549Geobacter sulfurreducens PCA, complete genomeketo/oxoacid ferredoxin oxidoreductase, gamma subunit2e-1685.5
NC_016751:1623756:164599316459931646589597Marinitoga piezophila KA3 chromosome, complete genome2-oxoacid:ferredoxin oxidoreductase subunit gamma3e-1684.7
NC_013939:913890:926661926661927200540Deferribacter desulfuricans SSM1, complete genome2-oxoglutarate ferredoxin oxidoreductase subunit gamma5e-1580.5
NC_015672:699904:715659715659716195537Flexistipes sinusarabici DSM 4947 chromosome, complete genome2-oxoglutarate synthase7e-1476.6
NC_007681:1532500:155703515570351557589555Methanosphaera stadtmanae DSM 3091, complete genomeKorC8e-1476.6
NC_015216:2422758:245005924500592450607549Methanobacterium sp. AL-21 chromosome, complete genome2-oxoglutarate synthase1e-1272.4
NC_009776:941964:959155959155959682528Ignicoccus hospitalis KIN4/I, complete genome2-oxoglutarate ferredoxin oxidoreductase, gamma subunit3e-1271.2
NC_014011:813645:833724833724834284561Aminobacterium colombiense DSM 12261 chromosome, complete genomePyruvate/ketoisovalerate oxidoreductase4e-1270.9
NC_012796:2090000:210666321066632107403741Desulfovibrio magneticus RS-1, complete genome2-oxoglutarate synthase subunit KorC8e-1270.1
NC_009712:669647:695465695465696001537Candidatus Methanoregula boonei 6A8, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase7e-1270.1
NC_014507:2276000:228294622829462283482537Methanoplanus petrolearius DSM 11571 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase1e-1169.3
NC_008346:36176:425024250243089588Syntrophomonas wolfei subsp. wolfei str. Goettingen, completeputative keto/oxoacid ferredoxin oxidoreductase, gamma subunit2e-1168.6
NC_006138:2630338:265159826515982652116519Desulfotalea psychrophila LSv54, complete genome2-ketoglutarate oxidoreductase, gamma chain2e-1168.6
NC_014633:837588:860646860646861167522Ilyobacter polytropus DSM 2926 plasmid pILYOP01, complete sequence2-oxoglutarate ferredoxin oxidoreductase subunit gamma5e-1167.4
NC_015499:1097432:110774511077451108314570Thermodesulfobium narugense DSM 14796 chromosome, complete genome2-oxoglutarate synthase1e-1066.2
NC_016629:4081500:409754540975454098174630Desulfovibrio africanus str. Walvis Bay chromosome, complete2-oxoglutarate synthase2e-1065.1
NC_010337:1188373:119503211950321195601570Heliobacterium modesticaldum Ice1, complete genome2-oxoacid:ferredoxin oxidoreductase, gamma subunit3e-1064.7
NC_013522:991649:101000410100041010561558Thermanaerovibrio acidaminovorans DSM 6589, complete genomepyruvate ferredoxin/flavodoxin oxidoreductase3e-1064.3
NC_020409:621792:632071632071632661591Desulfovibrio piezophilus str. nov C1TLV30 chromosome, complete2-oxoglutarate synthase subunit korC1e-0962.4
NC_014960:1735786:173640617364061737014609Anaerolinea thermophila UNI-1, complete genomeindolepyruvate oxidoreductase subunit IorB2e-0858.9
NC_013741:838243:849106849106849678573Archaeoglobus profundus DSM 5631, complete genomeindolepyruvate ferredoxin oxidoreductase, beta subunit3e-0651.6
NC_014538:1942500:194484019448401945415576Thermoanaerobacter sp. X513 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase, catalytic domain-containing protein6e-0650.4
NC_015499:491423:493698493698494273576Thermodesulfobium narugense DSM 14796 chromosome, complete genomepyruvate/ketoisovalerate oxidoreductase, gamma subunit6e-0650.4