Pre_GI: BLASTP Hits

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Query: NC_012563:3556763:3569531 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 3569531, End: 3569683, Length: 153

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:3185359:320055132005513200703153Clostridium botulinum A str. Hall chromosome, complete genomehypothetical protein2e-1891.3
NC_009697:3291500:330344433034443303596153Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein2e-1891.3
NC_009495:3309550:332745533274553327607153Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein2e-1891.3
NC_010516:3368951:338818233881823388766585Clostridium botulinum B1 str. Okra, complete genomehypothetical protein2e-1787.8
NC_012658:3387774:340600034060003406590591Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein1e-1684.7