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Query: NC_012563:2925472:2947085 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 2947085, End: 2947552, Length: 468

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:2017000:203416820341682034635468Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein6e-61232
NC_009699:2017329:203406220340622034529468Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein6e-61232
NC_010520:1614333:163658316365831637026444Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein7e-61232
NC_010516:2676746:269719726971972697670474Clostridium botulinum B1 str. Okra, complete genomehypothetical protein2e-2098.2
NC_009697:2558286:257855425785542579027474Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein3e-2097.4
NC_009699:3429817:345020534502053450678474Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein1e-1995.5
NC_017297:3428429:344881934488193449217399Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein2e-1994.7
NC_012563:1681639:170158617015861701948363Clostridium botulinum A2 str. Kyoto, complete genomeHNH endonuclease domain protein7e-1579.7
NC_014624:2878457:288551028855102885962453Eubacterium limosum KIST612 chromosome, complete genomeGp50 protein3e-1374.3
NC_010674:950276:953077953077953535459Clostridium botulinum B str. Eklund 17B, complete genomeHNH endonuclease domain protein3e-1167.4
NC_016791:1341858:134512613451261345548423Clostridium sp. BNL1100 chromosome, complete genomehypothetical protein6e-0960.1
UCMB5137:120656:131475131475131843369Bacillus atrophaeus UCMB-5137prophage Lp3 protein 122e-0754.7
NC_006270:3418097:345361934536193453993375Bacillus licheniformis ATCC 14580, complete genomeputative electron transporter3e-0754.3
NC_016935:1636278:165982416598241660165342Paenibacillus mucilaginosus 3016 chromosome, complete genomeelectron transporter5e-0753.5
NC_020272:1311932:133775513377551338120366Bacillus amyloliquefaciens IT-45, complete genomeHNH endonuclease4e-0650.4