Pre_GI: BLASTP Hits

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Query: NC_012563:2925472:2940793 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 2940793, End: 2941086, Length: 294

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:2101449:211643921164392116732294Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein4e-47186
NC_017297:2017000:202787920278792028172294Clostridium botulinum F str. 230613 chromosome, complete genomephage protein, phi-105 family2e-46183
NC_009699:2017329:202777320277732028066294Clostridium botulinum F str. Langeland chromosome, complete genomephi-105 family phage protein2e-46183
NC_010520:1614333:164295316429531643246294Clostridium botulinum A3 str. Loch Maree, complete genomephage protein, phi-105 family4e-45179
NC_015519:2489728:251671525167152517002288Tepidanaerobacter sp. Re1 chromosome, complete genomephage DNA packaging-like protein8e-1579
NC_014915:2963500:298413329841332984411279Geobacillus sp. Y412MC52 chromosome, complete genomeuncharacterized phage protein (putative DNA packaging)2e-1270.9
NC_013411:597235:619524619524619802279Geobacillus sp. Y412MC61, complete genomeuncharacterized phage protein (putative DNA packaging)2e-1270.9
NC_009674:2678932:269358426935842693874291Bacillus cytotoxicus NVH 391-98 chromosome, complete genomephage protein2e-0961.6
NC_016791:1341858:135165513516551351942288Clostridium sp. BNL1100 chromosome, complete genomephage QLRG family DNA packaging1e-0755.5
NC_006270:1511000:152120215212021521441240Bacillus licheniformis ATCC 14580, complete genomephage related protein8e-0752.4
NC_006322:1507411:152206315220631522302240Bacillus licheniformis ATCC 14580, complete genomehypothetical protein8e-0752.4
NC_020272:1311932:134440113444011344703303Bacillus amyloliquefaciens IT-45, complete genomehypothetical protein2e-0650.8
NC_006270:3418097:344688334468833447185303Bacillus licheniformis ATCC 14580, complete genomehypothetical phagelike protein5e-0650.1
NC_006322:3418268:344705434470543447356303Bacillus licheniformis ATCC 14580, complete genomehypothetical protein5e-0650.1