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Query: NC_012563:2925472:2939703 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 2939703, End: 2940059, Length: 357

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010520:1614333:164398016439801644336357Clostridium botulinum A3 str. Loch Maree, complete genomehypothetical protein3e-61233
NC_012563:2101449:211534921153492115705357Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein7e-60228
NC_017297:2017000:202679520267952027151357Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein7e-59225
NC_009699:2017329:202668920266892027045357Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein7e-59225
NC_014624:1235818:125516312551631255507345Eubacterium limosum KIST612 chromosome, complete genomehypothetical protein5e-1063.2
NC_015690:1186545:121822812182281218587360Paenibacillus mucilaginosus KNP414 chromosome, complete genomephage protein2e-0961.2
NC_014328:303063:373393373393373716324Clostridium ljungdahlii ATCC 49587 chromosome, complete genomehypothetical protein7e-0959.3
NC_009674:2678932:269248126924812692840360Bacillus cytotoxicus NVH 391-98 chromosome, complete genomehypothetical protein4e-0857
NC_014393:937000:966920966920967249330Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein8e-0855.8
NC_016935:1636278:166774316677431668048306Paenibacillus mucilaginosus 3016 chromosome, complete genomephage protein8e-0855.8
NC_013411:597235:620486620486620809324Geobacillus sp. Y412MC61, complete genomehypothetical protein7e-0855.8
NC_014915:2963500:298312629831262983449324Geobacillus sp. Y412MC52 chromosome, complete genomehypothetical protein7e-0855.8
NC_007530:3749645:376468637646863765045360Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein5e-0753.1
NC_005945:3747652:376505937650593765418360Bacillus anthracis str. Sterne, complete genomehypothetical protein5e-0753.1
NC_003997:3724702:376455937645593764918360Bacillus anthracis str. Ames, complete genomehypothetical protein5e-0753.1
NC_011658:2080390:208289420828942083253360Bacillus cereus AH187 chromosome, complete genomehypothetical protein5e-0753.1
NC_012581:466798:473772473772474131360Bacillus anthracis str. CDC 684 chromosome, complete genomehypothetical protein5e-0753.1
NC_012659:3724729:376458637645863764945360Bacillus anthracis str. A0248, complete genomehypothetical protein5e-0753.1
NC_016771:2039195:204172020417202042058339Bacillus cereus NC7401, complete genomehypothetical protein6e-0752.8
NC_021184:4493440:450376045037604504086327Desulfotomaculum gibsoniae DSM 7213, complete genomehypothetical protein6e-0752.8
NC_011773:4141765:415656741565674156941375Bacillus cereus AH820 chromosome, complete genomehypothetical protein1e-0651.6
NC_015519:2489728:251570525157052516031327Tepidanaerobacter sp. Re1 chromosome, complete genomehypothetical protein6e-0649.7
NC_020291:1122282:113198611319861132336351Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein DUF31688e-0649.3