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Query: NC_012563:2925472:2931078 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 2931078, End: 2932346, Length: 1269

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:2017000:201908920190892019910822Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein2e-112405
NC_009699:2017329:201898420189842019805822Clostridium botulinum F str. Langeland chromosome, complete genomehypothetical protein2e-112405
NC_010516:2305110:2312561231256123143661806Clostridium botulinum B1 str. Okra, complete genomeputative tail fiber protein8e-112404
NC_012563:2101449:2106528210652821079851458Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein2e-110399
NC_012658:2498087:2501771250177125036421872Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein2e-65249
NC_009697:3110772:3111110311111031125401431Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein3e-64246
NC_009697:2558286:2561437256143725628461410Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein3e-63242
NC_010516:2676746:2679631267963126812711641Clostridium botulinum B1 str. Okra, complete genomehypothetical protein5e-61235
NC_017297:3428429:3431398343139834330621665Clostridium botulinum F str. 230613 chromosome, complete genomeputative phage structural protein1e-59231
NC_009699:3429817:3432786343278634344501665Clostridium botulinum F str. Langeland chromosome, complete genomephage structural protein1e-59231
NC_018515:4660808:4667682466768246690581377Desulfosporosinus meridiei DSM 13257 chromosome, complete genomehypothetical protein4e-51202
NC_015519:2489728:250822825082282509175948Tepidanaerobacter sp. Re1 chromosome, complete genomehypothetical protein1e-37157
NC_012563:1704345:171852417185241719330807Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein2e-35150
NC_011837:2605409:263611626361162636619504Clostridium kluyveri NBRC 12016, complete genomehypothetical protein4e-33142
NC_009706:2673906:270461327046132705116504Clostridium kluyveri DSM 555 chromosome, complete genomephage structural protein4e-33142
NC_016791:4038069:404981340498134050316504Clostridium sp. BNL1100 chromosome, complete genomehypothetical protein4e-32139
NC_021184:4493440:4510138451013845112081071Desulfotomaculum gibsoniae DSM 7213, complete genomehypothetical protein7e-32138
NC_014915:2963500:297418729741872975089903Geobacillus sp. Y412MC52 chromosome, complete genomephage-related putative tail protein1e-31137
NC_013411:597235:628846628846629748903Geobacillus sp. Y412MC61, complete genomephage-related putative tail protein1e-31137
NC_015690:1186545:1228211122821112299201710Paenibacillus mucilaginosus KNP414 chromosome, complete genomehypothetical protein6e-23108
NC_016935:1636278:1677661167766116793731713Paenibacillus mucilaginosus 3016 chromosome, complete genomehypothetical protein9e-22105
NC_014393:2868846:2876211287621128772301020Clostridium cellulovorans 743B chromosome, complete genomehypothetical protein6e-1685.5
NC_016048:3899878:391889039188903919192303Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein3e-1480.1