Pre_GI: BLASTP Hits

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Query: NC_012563:2925472:2930133 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 2930133, End: 2930306, Length: 174

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:1704345:172014517201451720318174Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein2e-24110
NC_012563:2101449:210418021041802104353174Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein4e-2096.7
NC_010674:1986000:198793219879321988105174Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein4e-2199.8
NC_010674:2328307:233154723315472331720174Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein1e-1995.1
NC_010674:2817651:282220528222052822378174Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein2e-2097.4