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Query: NC_012563:2721658:2735894 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 2735894, End: 2736874, Length: 981

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012658:2584355:261950326195032620483981Clostridium botulinum Ba4 str. 657 chromosome, complete genomehypothetical protein9e-107386
NC_017200:4401945:4407989440798944091071119Bacillus thuringiensis serovar finitimus YBT-020 chromosome,sporulation integral membrane protein YtvI6e-0962
NC_012659:4399094:4403923440392344050411119Bacillus anthracis str. A0248, complete genomesporulation integral membrane protein YtvI6e-0962
NC_011658:4379274:4381691438169143828091119Bacillus cereus AH187 chromosome, complete genomesporulation integral membrane protein YtvI6e-0962
NC_005945:4399756:4404585440458544057031119Bacillus anthracis str. Sterne, complete genomehypothetical protein6e-0962
NC_014335:4327584:4332413433241343335311119Bacillus cereus biovar anthracis str. CI chromosome, completeputative transmembrane protein7e-0961.6
NC_003997:4399067:4403917440391744050141098Bacillus anthracis str. Ames, complete genomehypothetical protein7e-0961.6
NC_007530:4400152:4404044440404444051411098Bacillus anthracis str. 'Ames Ancestor', complete genomehypothetical protein7e-0961.6
NC_012472:4400420:4401444440144444025621119Bacillus cereus 03BB102, complete genomesporulation integral membrane protein YtvI7e-0961.6
NC_006274:4448293:4452306445230644534241119Bacillus cereus E33L, complete genomeconserved hypothetical protein; possible permease7e-0961.6
NC_016771:4333000:4335495433549543365921098Bacillus cereus NC7401, complete genomehypothetical protein7e-0961.6
NC_016779:4361140:4366113436611343672341122Bacillus cereus F837/76 chromosome, complete genomehypothetical protein7e-0961.6
NC_011773:4461758:4465629446562944667471119Bacillus cereus AH820 chromosome, complete genomesporulation integral membrane protein YtvI6e-0961.6
NC_011725:4562709:4563732456373245648501119Bacillus cereus B4264 chromosome, complete genomesporulation integral membrane protein YtvI1e-0861.2
NC_014171:4447856:4452684445268444538021119Bacillus thuringiensis BMB171 chromosome, complete genomehypothetical protein1e-0861.2
NC_009674:3344000:3349764334976433508821119Bacillus cytotoxicus NVH 391-98 chromosome, complete genomesporulation integral membrane protein YtvI6e-0858.5
NC_008346:983816:1004686100468610057981113Syntrophomonas wolfei subsp. wolfei str. Goettingen, completeprotein of unknown function UPF01182e-0653.5
NC_019970:8938:2548825488265521065Thermoanaerobacterium thermosaccharolyticum M0795, complete genomesporulation integral membrane protein YtvI4e-0652.4
NC_010184:4425676:4429546442954644306641119Bacillus weihenstephanensis KBAB4, complete genomeSporulation integral membrane protein YtvI8e-0651.6
NC_014410:8694:2523125231262951065Thermoanaerobacterium thermosaccharolyticum DSM 571 chromosome,sporulation integral membrane protein YtvI1e-0551.2