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Query: NC_012563:2680246:2695420 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 2695420, End: 2695794, Length: 375

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017297:2531750:256976225697622570139378Clostridium botulinum F str. 230613 chromosome, complete genomeDNA-binding protein9e-59224
NC_009699:2552195:256962225696222569999378Clostridium botulinum F str. Langeland chromosome, complete genomeDNA-binding protein9e-59224
NC_014393:937000:939498939498939920423Clostridium cellulovorans 743B chromosome, complete genomehelix-turn-helix domain-containing protein4e-0856.6
NC_014721:2135500:215777821577782158167390Caldicellulosiruptor kristjanssonii 177R1B chromosome, completehelix-turn-helix domain protein9e-0752.4
NC_009706:2023912:205875720587572058972216Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein2e-0651.6
NC_014721:2135500:215748921574892157689201Caldicellulosiruptor kristjanssonii 177R1B chromosome, completehelix-turn-helix domain protein1e-0651.6
NC_014219:3188128:320416132041613204748588Bacillus selenitireducens MLS10 chromosome, complete genometranscriptional regulator, XRE family6e-0649.7
NC_009253:897684:947474947474947677204Desulfotomaculum reducens MI-1 chromosome, complete genomeXRE family transcriptional regulator7e-0649.3
NC_013093:1213908:1225890122589012271011212Actinosynnema mirum DSM 43827, complete genometranscriptional regulator, XRE family8e-0649.3
NC_020387:796253:808932808932809591660Dehalococcoides mccartyi BTF08, complete genomeputative transcriptional repressor LexA9e-0648.9