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Query: NC_012563:2566500:2578059 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 2578059, End: 2578469, Length: 411

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009495:2479465:249005324900532490463411Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein2e-69260
NC_011837:3226500:326140332614033261813411Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-50197
NC_009706:3291330:332990133299013330311411Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein2e-50197
NC_009706:2023912:202461520246152025031417Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein4e-49192
NC_009633:2592000:260370826037082604118411Alkaliphilus metalliredigens QYMF chromosome, complete genomephage-like element PBSX protein3e-47186
NC_013406:6052913:607118060711806071587408Paenibacillus sp. Y412MC10 chromosome, complete genomeXkdM protein, phage-like element PBSX8e-47185
NC_014483:1179286:118608611860861186493408Paenibacillus polymyxa E681 chromosome, complete genomehypothetical protein7e-46182
NC_016641:2950000:295489629548962955303408Paenibacillus terrae HPL-003 chromosome, complete genomehypothetical protein9e-46181
NC_010674:2817651:283590728359072836329423Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein1e-36151
NC_013216:4404085:441065444106544411112459Desulfotomaculum acetoxidans DSM 771, complete genomehypothetical protein2e-27120
NC_015520:595532:613607613607614026420Mahella australiensis 50-1 BON chromosome, complete genomeXkdM protein, phage-like element PBSX2e-21100
NC_020291:795500:833919833919834350432Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomeXkdM protein, phage-like element PBSX2e-1477.4
NC_009617:3926843:394623339462333946664432Clostridium beijerinckii NCIMB 8052 chromosome, complete genomephage-like element pbsx protein XkdM3e-1270.5
NC_012491:3088500:309137730913773091811435Brevibacillus brevis NBRC 100599, complete genomehypothetical protein7e-1269.3
NC_017195:1308730:131079113107911311234444Bacillus subtilis subsp. subtilis str. RO-NN-1 chromosome, completehypothetical protein2e-1168.2
NC_019896:2719456:273640627364062736849444Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completePhage-like element PBSX protein XkdM2e-1168.2
NC_020244:1335531:133693313369331337376444Bacillus subtilis XF-1, complete genomehypothetical protein2e-1168.2
NC_000964:1330000:133311313331131333556444Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein2e-1168.2
NC_016047:1435961:143887314388731439316444Bacillus subtilis subsp. spizizenii TU-B-10 chromosome, completehypothetical protein3e-1167.4
UCMB5137:861734:870484870484870927444Bacillus atrophaeus UCMB-5137hypothetical protein3e-1167.4
NC_014976:627935:664179664179664622444Bacillus subtilis BSn5 chromosome, complete genomehypothetical protein5e-1166.6
NC_000964:2670288:267836926783692678812444Bacillus subtilis subsp. subtilis str. 168, complete genomehypothetical protein6e-1166.2
NC_012658:1405788:142145814214581421886429Clostridium botulinum Ba4 str. 657 chromosome, complete genomeputative phage protein XkdM1e-1065.1
NC_009848:2755874:276728427672842767727444Bacillus pumilus SAFR-032, complete genomehypothetical protein3e-1063.9
NC_016048:2563222:258399025839902584418429Oscillibacter valericigenes Sjm18-20, complete genomehypothetical protein1e-0652