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Query: NC_012563:2566500:2571425 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 2571425, End: 2571877, Length: 453

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009495:2479465:248340224834022483857456Clostridium botulinum A str. ATCC 3502 chromosome, complete genomehypothetical protein2e-63240
NC_011837:3226500:325101432510143251472459Clostridium kluyveri NBRC 12016, complete genomehypothetical protein7e-37152
NC_009706:3291330:331951233195123319970459Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein7e-37152
NC_009633:2592000:259817325981732598637465Alkaliphilus metalliredigens QYMF chromosome, complete genomephage-like element pbsx protein XkdS6e-36149
NC_009706:1935418:194037919403791940849471Clostridium kluyveri DSM 555 chromosome, complete genomehypothetical protein2e-33140
NC_009706:2003194:200874320087432009213471Clostridium kluyveri DSM 555 chromosome, complete genomeXkdS-like protein2e-33140
NC_011837:1935294:194025519402551940725471Clostridium kluyveri NBRC 12016, complete genomehypothetical protein2e-33140
NC_010674:2817651:282890028289002829340441Clostridium botulinum B str. Eklund 17B, complete genomehypothetical protein2e-30131
NC_016641:2950000:296006429600642960522459Paenibacillus terrae HPL-003 chromosome, complete genomehypothetical protein2e-2097.8
NC_013216:4404085:441817844181784418636459Desulfotomaculum acetoxidans DSM 771, complete genomehypothetical protein2e-2097.4
NC_014483:1179286:119125011912501191720471Paenibacillus polymyxa E681 chromosome, complete genomehypothetical protein4e-1993.6
NC_013406:6052913:606614460661446066602459Paenibacillus sp. Y412MC10 chromosome, complete genomehypothetical protein7e-1992.8
NC_014652:801653:827932827932828372441Caldicellulosiruptor hydrothermalis 108 chromosome, completehypothetical protein2e-1374.7
NC_012491:3704000:372445137244513724888438Brevibacillus brevis NBRC 100599, complete genomehypothetical protein2e-0961.2
NC_009617:3926843:394057939405793941019441Clostridium beijerinckii NCIMB 8052 chromosome, complete genomehypothetical protein6e-0856.6
NC_020291:795500:839539839539839979441Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomehypothetical protein DUF26347e-0752.8
NC_012491:3088500:309615830961583096595438Brevibacillus brevis NBRC 100599, complete genomehypothetical protein3e-0650.8
NC_020134:420500:447231447231447626396Clostridium stercorarium subsp. stercorarium DSM 8532, completephage-like element PBSX protein, XkdS6e-0650.1
NC_009012:2953638:296120429612042961599396Clostridium thermocellum ATCC 27405, complete genomehypothetical protein6e-0649.7
NC_014376:1472304:150627315062731506659387Clostridium saccharolyticum WM1 chromosome, complete genomehypothetical protein8e-0649.3