Pre_GI: BLASTP Hits

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Query: NC_012563:2566500:2568015 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 2568015, End: 2568176, Length: 162

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_012563:2925472:293060929306092930770162Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein3e-23107
NC_013315:1707293:172421617242161724398183Clostridium difficile CD196 chromosome, complete genomehypothetical protein8e-1165.9
NC_012563:2101449:210602121060212106188168Clostridium botulinum A2 str. Kyoto, complete genomehypothetical protein1e-1065.1
NC_009089:1093832:10873831087383114439857016Clostridium difficile 630, complete genome5e-1063.2
NC_017297:2531750:253266725326672532849183Clostridium botulinum F str. 230613 chromosome, complete genomehypothetical protein2e-0961.2
NC_009697:2558286:256091525609152561097183Clostridium botulinum A str. ATCC 19397 chromosome, completehypothetical protein4e-0960.1