Pre_GI: BLASTP Hits

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Query: NC_012563:122000:135432 Clostridium botulinum A2 str. Kyoto, complete genome

Start: 135432, End: 136814, Length: 1383

Host Lineage: Clostridium botulinum; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain was isolated from a case of infant botulism in Kyoto, Japan in 1978. This organism produces one of the most potent and deadly neurotoxins known, a botulinum toxin that prevents the release of acetylcholine at the neuromuscular junction, thereby inhibiting muscle contraction and causing paralysis. In most cases the diseased person dies of asphyxiation as a result of paralysis of chest muscles involved in breathing. The spores are heat-resistant and can survive in inadequately heated, prepared, or processed foods. Spores germinate under favorable conditions (anaerobiosis and substrate-rich environment) and bacteria start propagating very rapidly, producing the toxin.Botulinum toxin, and C. botulinum cells, has been found in a wide variety of foods, including canned ones. Almost any food that has a high pH (above 4.6) can support growth of the bacterium. Honey is the most common vehicle for infection in infants. Food poisoning through C. botulinum is the most frequent type of infection caused by this bacterium. The wound botulism that occurs when C. botulinum infects an individual via an open wound is much rarer and is very similar to tetanus disease. There are several types of botulinum toxin known (type A through type F), all of them being neurotoxic polypeptides. The most common and widely distributed are strains and serovars of C. botulinum that produce type A toxin.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_009698:120119:1343011343011356831383Clostridium botulinum A str. Hall chromosome, complete genomeradical SAM domain-containing protein0950
NC_009697:120117:1342991342991356811383Clostridium botulinum A str. ATCC 19397 chromosome, completeradical SAM domain-containing protein0950
NC_009495:128000:1414961414961428781383Clostridium botulinum A str. ATCC 3502 chromosome, complete genomeradical SAM domain protein0950
NC_017297:122383:1365701365701379521383Clostridium botulinum F str. 230613 chromosome, complete genomeradical SAM domain-containing protein0949
NC_009699:122000:1363051363051376871383Clostridium botulinum F str. Langeland chromosome, complete genomeradical SAM domain-containing protein0949
NC_010516:127000:1412891412891426711383Clostridium botulinum B1 str. Okra, complete genomeradical SAM domain protein0949
NC_010520:121077:1352831352831366651383Clostridium botulinum A3 str. Loch Maree, complete genomeradical SAM domain protein0943
NC_012658:125500:1389411389411403231383Clostridium botulinum Ba4 str. 657 chromosome, complete genomeradical SAM domain-containing protein0941
NC_014328:180482:2002222002222016041383Clostridium ljungdahlii ATCC 49587 chromosome, complete genomeputative Fe-S oxidoreductase0711
NC_021182:300415:3140133140133153921380Clostridium pasteurianum BC1, complete genomeputative Fe-S oxidoreductase0649
NC_014721:434501:4395624395624409591398Caldicellulosiruptor kristjanssonii 177R1B chromosome, completeradical sam domain protein3e-104379
NC_015519:2580310:2580310258031025816651356Tepidanaerobacter sp. Re1 chromosome, complete genomeRadical SAM domain-containing protein3e-94345
NC_014220:2037560:2037560203756020389151356Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomeRadical SAM domain protein1e-92340
NC_015172:1471501:1473392147339214747351344Syntrophobotulus glycolicus DSM 8271 chromosome, complete genomeRadical SAM domain protein1e-89330
NC_016751:1776669:1795990179599017974351446Marinitoga piezophila KA3 chromosome, complete genomeFe-S oxidoreductase2e-84313
NC_015738:873653:8756808756808771401461Eggerthella sp. YY7918, complete genomehypothetical protein7e-82304
NC_008942:1198000:1212568121256812137311164Methanocorpusculum labreanum Z, complete genomehypothetical protein3e-37156
NC_013741:1068170:1086027108602710874151389Archaeoglobus profundus DSM 5631, complete genomeRadical SAM domain protein5e-1995.9
NC_015589:1630461:165416316541631655155993Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeRadical SAM domain-containing protein2e-1790.5
NC_018876:2380018:2394099239409923951541056Methanolobus psychrophilus R15 chromosome, complete genomeradical SAM family Fe-S protein4e-1686.7
NC_019977:828427:8429508429508441071158Methanomethylovorans hollandica DSM 15978, complete genomeputative heme d1 biosynthesis radical SAM protein NirJ26e-1685.9
NC_012470:1946968:1963790196379019649081119Streptococcus equi subsp. zooepidemicus, complete genomeRadical SAM superfamily protein2e-1584.3
NC_003552:661579:6772296772296782781050Methanosarcina acetivorans C2A, complete genomeheme d1 biosynthesis protein NirJ2e-1480.9
NC_018876:2380018:2396813239681323980031191Methanolobus psychrophilus R15 chromosome, complete genomeradical SAM family Fe-S protein3e-1480.5
NC_018870:2537350:2547893254789325489151023Thermacetogenium phaeum DSM 12270 chromosome, complete genomecoenzyme PQQ synthesis protein E6e-1479.3
NC_015320:790137:8092578092578104171161Archaeoglobus veneficus SNP6 chromosome, complete genomeRadical SAM domain-containing protein2e-1377.4
NC_010814:3332088:3341308334130833423721065Geobacter lovleyi SZ, complete genomeRadical SAM domain protein5e-1376.3
NC_009033:653462:6708496708496723691521Staphylothermus marinus F1, complete genomeRadical SAM domain protein5e-1376.3
NC_013939:1460142:1471512147151214725761065Deferribacter desulfuricans SSM1, complete genomeradical SAM domain protein4e-1273.2
NC_008553:329458:3473143473143483931080Methanosaeta thermophila PT, complete genomeRadical SAM domain protein5e-1272.8
NC_019977:828427:8457208457208469041185Methanomethylovorans hollandica DSM 15978, complete genomeputative Fe-S oxidoreductase1e-1171.6
NC_012623:1631985:1631985163198516331211137Sulfolobus islandicus Y.N.15.51 chromosome, complete genomeradical SAM protein2e-1170.9
NC_012622:940990:9590429590429601781137Sulfolobus islandicus Y.G.57.14 chromosome, complete genomeradical SAM protein2e-1170.9
NC_014314:404315:4219644219644231091146Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completeradical SAM domain-containing protein1e-1068.2
NC_020389:1777409:179374717937471794421675Methanosarcina mazei Tuc01, complete genomeRadical SAM domain heme biosynthesis protein2e-1067.8
NC_020134:205000:215390215390216313924Clostridium stercorarium subsp. stercorarium DSM 8532, completeputative Fe-S oxidoreductase9e-1065.5
NC_016584:3847663:3857614385761438590381425Desulfosporosinus orientis DSM 765 chromosome, complete genomeradical SAM additional 4Fe4S-binding domain-containing protein8e-1065.5
NC_020304:129321:1501321501321511661035Desulfocapsa sulfexigens DSM 10523, complete genomeradical SAM additional 4Fe4S-binding domain-containing protein2e-0964.3
NC_015416:1039144:104021210402121041177966Methanosaeta concilii GP-6 chromosome, complete genomeradical SAM domain-containing protein2e-0963.9
NC_011653:331986:333172333172334122951Thermosipho africanus TCF52B, complete genomeAstB/chuR-related protein4e-0963.2
NC_015388:2921000:2941115294111529426501536Desulfobacca acetoxidans DSM 11109 chromosome, complete genomeRadical SAM domain protein6e-0962.4
NC_002754:1661000:1665410166541016665461137Sulfolobus solfataricus P2, complete genomeCoenzyme PQQ synthesis protein E (pqqE-4)7e-0962.4
NC_015873:1193843:1203710120371012050201311Megasphaera elsdenii DSM 20460, complete genomehypothetical protein2e-0861.2
NC_015500:484984:4982864982864998001515Treponema brennaborense DSM 12168 chromosome, complete genomeRadical SAM domain protein3e-0860.1
NC_006448:1709523:1727366172736617286401275Streptococcus thermophilus LMG 18311, complete genomehypothetical protein7e-0859.3
NC_006449:1714994:1729235172923517305091275Streptococcus thermophilus CNRZ1066, complete genomehypothetical protein7e-0859.3
NC_008554:4839116:4839116483911648401771062Syntrophobacter fumaroxidans MPOB, complete genomeRadical SAM domain protein7e-0858.9
NC_009635:94937:112163112163113035873Methanococcus aeolicus Nankai-3 chromosome, complete genomeradical SAM domain-containing protein8e-0858.9
NC_018867:1161648:1172852117285211739761125Dehalobacter sp. CF chromosome, complete genomeRadical SAM domain protein8e-0858.9
NC_015436:474710:490810490810491742933Spirochaeta coccoides DSM 17374 chromosome, complete genomeRadical SAM domain-containing protein1e-0758.2
NC_007955:1498777:1504829150482915060401212Methanococcoides burtonii DSM 6242, complete genomeFe-S protein, radical SAM family1e-0758.2
NC_011883:1478173:1497826149782614988601035Desulfovibrio desulfuricans subsp. desulfuricans str. ATCC 27774,molybdenum cofactor biosynthesis protein A1e-0758.2
NC_013665:849508:8828538828538839801128Methanocella paludicola SANAE, complete genomehypothetical protein1e-0758.2
NC_009616:99647:9964799647100597951Thermosipho melanesiensis BI429 chromosome, complete genomeradical SAM domain-containing protein2e-0757.8
NC_014507:2479221:2494030249403024950611032Methanoplanus petrolearius DSM 11571 chromosome, complete genomeRadical SAM domain-containing protein2e-0757.4
NC_007759:1419171:1427682142768214291151434Syntrophus aciditrophicus SB, complete genomeradical SAM superfamily protein2e-0757.4
NC_008701:37219:4525245252464211170Pyrobaculum islandicum DSM 4184, complete genomeRadical SAM domain protein6e-0755.8
NC_013204:3419817:3428723342872334301501428Eggerthella lenta DSM 2243, complete genomeRadical SAM domain protein6e-0755.8
NC_015589:1630461:1651864165186416530301167Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeRadical SAM domain-containing protein7e-0755.8
NC_015216:2548057:256204625620462563008963Methanobacterium sp. AL-21 chromosome, complete genomemolybdenum cofactor biosynthesis protein A9e-0755.5
NC_014033:2080818:2095787209578720971241338Prevotella ruminicola 23 chromosome, complete genomeputative Fe-S oxidoreductase8e-0755.5
NC_012470:1370418:1380446138044613814771032Streptococcus equi subsp. zooepidemicus, complete genomeradical SAM superfamily protein8e-0755.5
NC_015589:2209011:2223858222385822251891332Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeRadical SAM domain-containing protein1e-0655.1
NC_018876:2189798:219836621983662199208843Methanolobus psychrophilus R15 chromosome, complete genomehypothetical protein1e-0654.7
NC_012622:1646000:166626716662671667235969Sulfolobus islandicus Y.G.57.14 chromosome, complete genomeradical SAM protein3e-0653.9
NC_012623:960327:959388959388960356969Sulfolobus islandicus Y.N.15.51 chromosome, complete genomeradical SAM protein3e-0653.9
NC_013769:1705500:172742517274251728393969Sulfolobus islandicus L.D.8.5 chromosome, complete genomeradical SAM protein3e-0653.9
NC_017275:1635959:165847316584731659441969Sulfolobus islandicus HVE10/4 chromosome, complete genomeradical SAM domain-containing protein3e-0653.9
NC_017276:1491473:151398815139881514956969Sulfolobus islandicus REY15A chromosome, complete genomeradical SAM domain-containing protein3e-0653.9
NC_014314:404315:4207894207894219671179Dehalogenimonas lykanthroporepellens BL-DC-9 chromosome, completeradical SAM domain-containing protein2e-0653.9
NC_012726:1611936:163439216343921635360969Sulfolobus islandicus M.16.4 chromosome, complete genomeradical SAM protein2e-0653.9
NC_012588:1585808:160826216082621609230969Sulfolobus islandicus M.14.25 chromosome, complete genomeradical SAM protein3e-0653.5
NC_014844:1773424:1786864178686417879161053Desulfovibrio aespoeensis Aspo-2 chromosome, complete genomeRadical SAM domain-containing protein3e-0653.5