Pre_GI: BLASTP Hits

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Query: NC_012440:1249941:1267468 Persephonella marina EX-H1, complete genome

Start: 1267468, End: 1268463, Length: 996

Host Lineage: Persephonella marina; Persephonella; Hydrogenothermaceae; Aquificales; Aquificae; Bacteria

General Information: This species is a chemolithotrophic, thermophilic hydrogen-oxidizing bacterium. This strain was collected from a deep sea hydrothermal vent on the East Pacific Rise.




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Host Information, e.g. soil, Thermo, Russia



SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017096:260333:268140268140269120981Caldisericum exile AZM16c01, complete genomeputative CRISPR-associated protein1e-103376
NC_014206:1467000:147764014776401478626987Geobacillus sp. C56-T3 chromosome, complete genomeCRISPR-associated protein Cas11e-93343
NC_013216:921377:930756930756931748993Desulfotomaculum acetoxidans DSM 771, complete genomeCRISPR-associated protein Cas11e-86320
NC_017161:1117741:112520611252061126195990Hydrogenobacter thermophilus TK-6 chromosome, complete genomeCRISPR-associated protein Cas12e-85316
NC_013799:1117750:112534811253481126337990Hydrogenobacter thermophilus TK-6, complete genomeCRISPR-associated protein2e-85316
NC_019942:1370872:137585613758561376827972Aciduliprofundum sp. MAR08-339, complete genomeCRISPR-associated endonuclease Cas12e-83309
NC_010803:483713:4974894974894986431155Chlorobium limicola DSM 245, complete genomeCRISPR-associated protein Cas16e-83307
NC_014150:1423758:142659114265911427583993Brachyspira murdochii DSM 12563 chromosome, complete genomeCRISPR-associated protein Cas18e-83307
NC_015975:1056731:106910110691011070090990Lactobacillus ruminis ATCC 27782 chromosome, complete genomeCRISPR-associated protein cas13e-80298
NC_016610:2489415:2506848250684825078641017Tannerella forsythia ATCC 43037 chromosome, complete genomeCRISPR-associated endonuclease Cas1, HMARI/TNEAP subtype2e-79295
NC_000916:983500:99965899965810006621005Methanothermobacter thermautotrophicus str. Delta H, completehypothetical protein5e-79294
NC_013526:567500:579575579575580567993Thermobaculum terrenum ATCC BAA-798 chromosome 2, complete genomeCRISPR-associated protein Cas17e-78290
NC_020134:1783000:178970717897071790699993Clostridium stercorarium subsp. stercorarium DSM 8532, completeCRISPR-associated endonuclease Cas11e-77290
NC_013501:1881692:1890300189030018913821083Rhodothermus marinus DSM 4252, complete genomeCRISPR-associated protein Cas12e-77289
NC_015966:1316901:1338083133808313391651083Rhodothermus marinus SG0.5JP17-172 chromosome, complete genomeCRISPR-associated protein Cas14e-77288
NC_008148:258292:263671263671264666996Rubrobacter xylanophilus DSM 9941, complete genomeCRISPR-associated protein Cas11e-76286
NC_014915:332784:3474673474673484681002Geobacillus sp. Y412MC52 chromosome, complete genomeCRISPR-associated protein Cas14e-76285
NC_009718:1024000:103198110319811032973993Fervidobacterium nodosum Rt17-B1, complete genomeCRISPR-associated Cas1 family protein2e-75282
NC_015571:290355:3009043009043019201017Porphyromonas gingivalis TDC60, complete genomeCRISPR-associated Cas1 family protein1e-74280
NC_002950:2098454:2104579210457921055951017Porphyromonas gingivalis W83, complete genomeCRISPR-associated protein Cas11e-74280
NC_014209:2204515:220734922073492208341993Thermoanaerobacter mathranii subsp. mathranii str. A3 chromosome,CRISPR-associated protein Cas11e-74280
NC_011296:1039749:107289410728941073886993Thermodesulfovibrio yellowstonii DSM 11347, complete genomeCRISPR-associated protein Cas1, HMARI/TNEAP subtype8e-75280
NC_007955:1198994:1211168121116812121691002Methanococcoides burtonii DSM 6242, complete genomeCRISPR-associated protein Cas17e-74277
NC_010003:2056000:2074113207411320751141002Petrotoga mobilis SJ95, complete genomeCRISPR-associated protein Cas12e-73276
NC_021184:823000:831502831502832494993Desulfotomaculum gibsoniae DSM 7213, complete genomeCRISPR-associated endonuclease Cas12e-73276
NC_011978:699500:712068712068713057990Thermotoga neapolitana DSM 4359, complete genomeCRISPR-associated protein, Cas1 family2e-73275
NC_015589:3053504:306154730615473062539993Desulfotomaculum ruminis DSM 2154 chromosome, complete genomeCRISPR-associated protein Cas14e-73275
NC_009486:1103915:111051411105141111497984Thermotoga petrophila RKU-1 chromosome, complete genomeCRISPR-associated Cas1 family protein8e-73274
NC_007681:1082000:1089890108989010908941005Methanosphaera stadtmanae DSM 3091, complete genomehypothetical protein8e-73274
NC_016884:3219030:324977132497713250763993Sulfobacillus acidophilus DSM 10332 chromosome, complete genomeCRISPR-associated protein Cas14e-70265
NC_019897:3251639:328546532854653286457993Thermobacillus composti KWC4 chromosome, complete genomeCRISPR-associated endonuclease Cas14e-69261
NC_000961:135493:152194152194153147954Pyrococcus horikoshii OT3, complete genomehypothetical protein1e-65250
NC_015680:841783:847625847625848593969Pyrococcus yayanosii CH1 chromosome, complete genomeCRISPR-associated protein Cas11e-65250
NC_016051:460624:467247467247468227981Thermococcus sp. AM4 chromosome, complete genomeCRISPR-associated protein Cas12e-65249
NC_013926:974668:978811978811979776966Aciduliprofundum boonei T469 chromosome, complete genomeCRISPR-associated protein Cas11e-64246
NC_015757:2343193:237170123717012372588888Sulfobacillus acidophilus TPY chromosome, complete genomeCRISPR-associated Cas1 family protein3e-64245
NC_015865:685882:699503699503700483981Thermococcus sp. 4557 chromosome, complete genomeCRISPR-associated protein Cas13e-63242
NC_007681:482445:488802488802489800999Methanosphaera stadtmanae DSM 3091, complete genomehypothetical protein4e-63241
NC_014624:140000:148305148305149303999Eubacterium limosum KIST612 chromosome, complete genomeCRISPR-associated protein Cas13e-62239
NC_015634:2492771:2503512250351225045131002Bacillus coagulans 2-6 chromosome, complete genomecrispr-associated protein Cas16e-62238
NC_015387:2072237:208212420821242083110987Marinithermus hydrothermalis DSM 14884 chromosome, complete genomeCRISPR-associated protein Cas13e-61235
NC_009718:1470972:149663514966351497624990Fervidobacterium nodosum Rt17-B1, complete genomeCRISPR-associated Cas1 family protein7e-61234
NC_011653:310000:324987324987325970984Thermosipho africanus TCF52B, complete genomecas crispr-associated protein Cas12e-53209
NC_002689:78297:110910110910111878969Thermoplasma volcanium GSS1, complete genomehypothetical protein1e-47190
NC_014935:1047411:106159210615921062590999Nitratifractor saLSUginis DSM 16511 chromosome, complete genomecrispr-associated protein, cas1 family3e-47189
NC_009715:873280:879066879066880064999Campylobacter curvus 525.92 chromosome, complete genomeCRISPR-associated protein Cas12e-45182
NC_013510:1023348:104294310429431043923981Thermomonospora curvata DSM 43183, complete genomeCRISPR-associated protein Cas17e-42171
NC_012438:776260:789257789257789661405Sulfurihydrogenibium azorense Az-Fu1 chromosome, complete genomeCRISPR-associated protein Cas13e-41169
NC_009523:5438000:5442373544237354434041032Roseiflexus sp. RS-1 chromosome, complete genomeCRISPR-associated Cas1 family protein2e-28126
NC_014364:1116439:1126787112678711278121026Spirochaeta smaragdinae DSM 11293 chromosome, complete genomeCRISPR-associated protein Cas17e-28124
NC_005085:1269787:1291807129180712928471041Chromobacterium violaceum ATCC 12472, complete genomehypothetical protein1e-26120
NC_007759:2748000:2753501275350127545321032Syntrophus aciditrophicus SB, complete genomehypothetical cytosolic protein2e-26119
NC_013740:842841:8807038807038817341032Acidaminococcus fermentans DSM 20731, complete genomeCRISPR-associated protein Cas14e-26119
NC_008618:1456000:1462586146258614636171032Bifidobacterium adolescentis ATCC 15703, complete genomeCRISPR-associated DNA polymerase4e-26119
NC_013714:1830959:1837314183731418383451032Bifidobacterium dentium Bd1, complete genomeCRISPR-associated protein Cas17e-26118
NC_014960:1380500:1384573138457313856041032Anaerolinea thermophila UNI-1, complete genomehypothetical protein1e-25117
NC_014836:1108919:1129474112947411304751002Desulfurispirillum indicum S5 chromosome, complete genomeCRISPR-associated protein Cas12e-25116
NC_010995:2798000:2802757280275728037731017Cellvibrio japonicus Ueda107, complete genomeCRISPR-associated protein Cas12e-25116
NC_007777:3962000:3969767396976739708011035Frankia sp. CcI3, complete genomeCRISPR-associated protein Cas14e-25115
NC_014484:447889:4595874595874606211035Spirochaeta thermophila DSM 6192 chromosome, complete genomehypothetical protein2e-24113
NC_021175:353292:3632773632773643021026Streptococcus oligofermentans AS 1.3089, complete genomeCRISPR-associated protein Cas12e-24113
NC_017218:1655009:1661694166169416627251032Bifidobacterium breve ACS-071-V-Sch8b chromosome, complete genomeCRISPR-associated endonuclease Cas1, subtype I-C/DVULG3e-24112
NC_002939:47406:7263072630743091680Geobacter sulfurreducens PCA, complete genomeCRISPR-associated protein Cas1/Cas44e-24112
NC_011060:1746000:1760549176054917615801032Pelodictyon phaeoclathratiforme BU-1, complete genomeCRISPR-associated protein Cas14e-24112
NC_016906:3980122:3984422398442239860771656Gordonia polyisoprenivorans VH2 chromosome, complete genomeCRISPR-associated protein, Cas1/Cas41e-23110
NC_015387:261799:2725382725382735601023Marinithermus hydrothermalis DSM 14884 chromosome, complete genomeCRISPR-associated protein Cas11e-23110
NC_015677:3685452:3697862369786236989021041Ramlibacter tataouinensis TTB310 chromosome, complete genomeCRISPR-associated protein Cas11e-23110
NC_007426:1558804:157753715775371578532996Natronomonas pharaonis DSM 2160, complete genomehypothetical protein2e-23110
NC_013502:102430:1225601225601242211662Rhodothermus marinus DSM 4252 plasmid pRMAR01, complete sequenceCRISPR-associated protein Cas12e-23110
NC_012470:1606000:1606559160655916075841026Streptococcus equi subsp. zooepidemicus, complete genomeCRISPR-associated protein Cas12e-23109
NC_007947:621213:6310996310996321151017Methylobacillus flagellatus KT, complete genomeCRISPR-associated protein Cas13e-22106
NC_005823:1105524:113475111347511135605855Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130hypothetical protein4e-22105
NC_020126:9726992:9733543973354397345711029Myxococcus stipitatus DSM 14675, complete genomeCRISPR-associated Cas1 family protein4e-22105
NC_007512:1459685:1471690147169014727211032Pelodictyon luteolum DSM 273, complete genomeProtein of unknown function DUF488e-22104
NC_013204:2305140:2312845231284523138761032Eggerthella lenta DSM 2243, complete genomeCRISPR-associated protein Cas19e-22104
NC_014221:1786122:1803738180373818047691032Truepera radiovictrix DSM 17093 chromosome, complete genomeCRISPR-associated protein Cas12e-21103
NC_008554:1664131:1682181168218116832331053Syntrophobacter fumaroxidans MPOB, complete genomeCRISPR-associated protein Cas14e-21102
NC_012814:1494331:1509955150995515114451491Bifidobacterium animalis subsp. lactis Bl-04, complete genomeCRISPR-associated Cas1/Cas4 family protein2e-20100
NC_017217:1499832:1515456151545615169461491Bifidobacterium animalis subsp. lactis V9 chromosome, completeCRISPR-associated Cas1/Cas4 family protein2e-20100
NC_017214:191791:2074152074152090461632Bifidobacterium animalis subsp. lactis BB-12 chromosome, completehypothetical protein2e-20100
NC_017215:1499179:1514803151480315164341632Bifidobacterium animalis subsp. lactis CNCM I-2494 chromosome,hypothetical protein2e-20100
NC_017216:1494190:1509814150981415114031590Bifidobacterium animalis subsp. lactis BLC1, complete genomeCRISPR-associated Cas1-Cas4 family protein2e-20100
NC_008639:2358592:2392804239280423938471044Chlorobium phaeobacteroides DSM 266, complete genomeCRISPR-associated protein Cas13e-2099.8
NC_009337:1448607:1459865145986514608961032Chlorobium phaeovibrioides DSM 265 chromosome, complete genomeCRISPR-associated Cas1 family protein2e-2099.8
NC_011835:625472:6410986410986427051608Bifidobacterium animalis subsp. lactis AD011 chromosome, completeCRISPR-associated protein Cas12e-2099.8
NC_012815:1494263:1509887150988715113771491Bifidobacterium animalis subsp. lactis DSM 10140, complete genomeCRISPR-associated Cas1/Cas4 family protein2e-2099.8
NC_009615:1354122:1378926137892613799481023Parabacteroides distasonis ATCC 8503 chromosome, complete genomehypothetical protein3e-2099.4
NC_015388:1913118:1932998193299819340471050Desulfobacca acetoxidans DSM 11109 chromosome, complete genomeCRISPR-associated protein Cas13e-2099.4
NC_014933:3637172:3658386365838636594081023Bacteroides helcogenes P 36-108 chromosome, complete genomeCRISPR-associated protein, Cas1 family3e-2099.4
NC_016630:28410:3992739927409581032Filifactor alocis ATCC 35896 chromosome, complete genomeCRISPR-associated protein Cas14e-2099
NC_015976:1893076:1914216191421619152561041Sphingobium sp. SYK-6, complete genomeCRISPR-associated protein Cas16e-2098.6
NC_014212:670996:696687696687697658972Meiothermus silvanus DSM 9946 chromosome, complete genomeCRISPR-associated protein Cas19e-2097.8
NC_015954:189000:195069195069196064996Halophilic archaeon DL31 chromosome, complete genomeCRISPR-associated protein Cas11e-1997.4
NC_010610:1385066:1394192139419213952231032Lactobacillus fermentum IFO 3956, complete genomehypothetical protein2e-1997.1
NC_016584:1912000:1925064192506419260951032Desulfosporosinus orientis DSM 765 chromosome, complete genomeCRISPR-associated endonuclease Cas12e-1997.1
NC_006513:1949751:1954058195405819550861029Azoarcus sp. EbN1, complete genomehypothetical protein7e-1994.7
NC_016012:665171:669185669185670084900Candidatus Arthromitus sp. SFB-rat-Yit, complete genomeCRISPR-associated Cas1 family protein9e-1994.7
NC_011963:1979136:1993468199346819945021035Rhodobacter sphaeroides KD131 chromosome 1, complete sequenceCRISPR-associated protein, Cas1 family1e-1894.4
NC_011420:3582500:3605316360531636063681053Rhodospirillum centenum SW, complete genomeCRISPR-associated protein Cas1, putative2e-1893.2
NC_008741:15699:3309633096341271032Desulfovibrio vulgaris subsp. vulgaris DP4 plasmid pDVUL01,CRISPR-associated protein Cas13e-1892.8
NC_010803:1009000:1012746101274610149412196Chlorobium limicola DSM 245, complete genomeCRISPR-associated protein Cas13e-1892.8
NC_004757:905417:919923919923920549627Nitrosomonas europaea ATCC 19718, complete genomeProtein of unknown function DUF484e-1892.4
NC_013715:1376985:1377284137728413789661683Rothia mucilaginosa DY-18, complete genomeuncharacterized protein predicted to be involved in DNA repair1e-1790.5
NC_008095:8837612:8862974886297488646801707Myxococcus xanthus DK 1622, complete genomeCRISPR-associated fusion protein Cas4/Cas13e-1789.7
NC_015873:1487127:149357914935791494574996Megasphaera elsdenii DSM 20460, complete genomeCRISPR-associated endonuclease CaS18e-1788.2
NC_013235:1354443:136212413621241362708585Nakamurella multipartita DSM 44233, complete genome1e-1687.4
NC_008639:2358592:2379403237940323815982196Chlorobium phaeobacteroides DSM 266, complete genomeCRISPR-associated protein Cas11e-1687.4
NC_012438:776260:789615789615789965351Sulfurihydrogenibium azorense Az-Fu1 chromosome, complete genomeCRISPR-associated protein Cas12e-1687
NC_009718:1771500:1778303177830317793071005Fervidobacterium nodosum Rt17-B1, complete genomeCRISPR-associated Cas1 family protein4e-1685.9
NC_010803:1009000:100906110090611009684624Chlorobium limicola DSM 245, complete genomeCRISPR-associated protein Cas15e-1685.5
NC_011060:2525367:2541825254182525440082184Pelodictyon phaeoclathratiforme BU-1, complete genomeCRISPR-associated protein Cas18e-1684.7
NC_014215:421683:4441674441674457681602Propionibacterium freudenreichii subsp. shermanii CIRM-BIA1,CRISPR-associated protein Cas1/Cas49e-1684.7
NC_020126:10091703:1009895710098957101006121656Myxococcus stipitatus DSM 14675, complete genomeCRISPR-associated Cas1 family protein2e-1583.2
NC_006300:1624254:1631470163147016324711002Mannheimia succiniciproducens MBEL55E, complete genomehypothetical protein2e-1480.1
NC_015573:2975000:2978252297825229792621011Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomeCRISPR-associated protein Cas15e-1478.6
NC_014002:1308458:1322759132275913239761218Methanohalophilus mahii DSM 5219 chromosome, complete genomeCRISPR-associated protein, Cas1 family8e-1478.2
NC_012108:616088:6208976208976219131017Desulfobacterium autotrophicum HRM2, complete genomeputative CRISPR-associated protein (uncharacterized protein, predicted to be involved in DNA repair)2e-1376.6
NC_009525:3128786:3135958313595831369741017Mycobacterium tuberculosis H37Ra, complete genomehypothetical protein4e-1375.9
NC_002945:3073370:3080529308052930815451017Mycobacterium bovis AF2122/97, complete genomehypothetical protein4e-1375.9
NC_002755:3110929:3118172311817231191881017Mycobacterium tuberculosis CDC1551, complete genomeCRISPR-associated protein Cas14e-1375.9
NC_000962:3116818:3123967312396731249831017Mycobacterium tuberculosis H37Rv, complete genomehypothetical protein4e-1375.9
NC_008769:3070266:3077944307794430789601017Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein4e-1375.9
NC_018876:168207:1946661946661958801215Methanolobus psychrophilus R15 chromosome, complete genomeCRISPR-associated protein, Cas1 family4e-1375.9
NC_019950:3139865:3148337314833731493531017Mycobacterium canettii CIPT 140060008 complete genomePutative CRISPR-associated metal-dependent deoxyribonuclease Cas14e-1375.9
NC_015848:3175692:3183954318395431849701017Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein4e-1375.9
NC_009565:3128094:3135596313559631366121017Mycobacterium tuberculosis F11, complete genomehypothetical protein4e-1375.9
NC_012207:3063039:3070717307071730717331017Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein4e-1375.9
NC_016768:1279178:1288797128879712898131017Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein4e-1375.9
NC_016804:3049631:3057309305730930583251017Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein4e-1375.9
NC_017026:3110155:3117810311781031188261017Mycobacterium tuberculosis RGTB327 chromosome, complete genomeCRISPR-associated protein Cas14e-1375.9
NC_012943:1279228:1288844128884412898691026Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein4e-1375.9
NC_013385:1758383:1760208176020817612181011Ammonifex degensii KC4, complete genomeCRISPR-associated protein Cas17e-1375.1
NC_009921:1668306:168514316851431686124982Frankia sp. EAN1pec, complete genome9e-1374.7
NC_014471:849032:867168867168868145978Ignisphaera aggregans DSM 17230 chromosome, complete genomeCRISPR-associated protein Cas12e-1273.2
NC_015577:3364985:3384752338475233857681017Treponema azotonutricium ZAS-9 chromosome, complete genomeCRISPR-associated protein Cas17e-1271.6
NC_010337:524605:5246055246055256991095Heliobacterium modesticaldum Ice1, complete genomecrispr-associated protein cas17e-1271.6
NC_009973:77518:99827998271008401014Herpetosiphon aurantiacus ATCC 23779 plasmid pHAU01, completeCRISPR-associated Cas1 family protein1e-1171.2
NC_011901:1916602:1917250191725019193252076Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, completeCRISPR-associated protein Cas12e-1170.5
NC_015416:2723189:2758297275829727594211125Methanosaeta concilii GP-6 chromosome, complete genomecrispr-associated protein Cas12e-1170.1
NC_010794:800951:827260827260827913654Methylacidiphilum infernorum V4, complete genomeCRISPR-associated protein Cas14e-1169.3
NC_010424:1356000:136149613614961362416921Candidatus Desulforudis audaxviator MP104C, complete genomeCRISPR-associated protein Cas15e-1168.9
NC_003901:678340:683642683642684613972Methanosarcina mazei Go1, complete genomehypothetical protein9e-1168.2
NC_020389:571466:578765578765579664900Methanosarcina mazei Tuc01, complete genomeCRISPR-associated protein Cas18e-1168.2
NC_014926:1483974:149505014950501495946897Thermovibrio ammonificans HB-1 chromosome, complete genomeCRISPR-associated protein Cas12e-1067
NC_011899:1603500:162508916250891626066978Halothermothrix orenii H 168, complete genomeCRISPR-associated protein Cas13e-1066.2
NC_015416:2838020:2842091284209128431041014Methanosaeta concilii GP-6 chromosome, complete genomecrispr-associated protein Cas13e-1066.2
NC_019978:922978:9325859325859336011017Halobacteroides halobius DSM 5150, complete genomeCRISPR-associated endonuclease Cas16e-1065.1
NC_015388:89000:1017711017711027841014Desulfobacca acetoxidans DSM 11109 chromosome, complete genomeCRISPR-associated protein Cas13e-0962.8
NC_009712:669647:675274675274676206933Candidatus Methanoregula boonei 6A8, complete genomeCRISPR-associated Cas1 family protein6e-0962
NC_018876:168207:1822301822301834321203Methanolobus psychrophilus R15 chromosome, complete genomeCRISPR-associated protein, Cas1 family1e-0861.2
NC_010729:2147268:214726821472682148026759Porphyromonas gingivalis ATCC 33277, complete genomehypothetical protein3e-0859.7
NC_002950:2068500:2069615206961520727103096Porphyromonas gingivalis W83, complete genomeCRISPR-associated protein Cas17e-0858.5
NC_015571:260664:2606642606642637593096Porphyromonas gingivalis TDC60, complete genomeCRISPR-associated Cas1 family protein1e-0757.4
NC_000854:770000:784519784519785502984Aeropyrum pernix K1, complete genomeputative CRISPR-associated protein Cas12e-0757.4
NC_012632:943104:943104943104944018915Sulfolobus islandicus M.16.27 chromosome, complete genomeCRISPR-associated protein Cas15e-0755.8
NC_014537:1589125:161406816140681615063996Vulcanisaeta distributa DSM 14429 chromosome, complete genomeCRISPR-associated protein Cas16e-0755.5
NC_009464:2687445:2699942269994227011621221Uncultured methanogenic archaeon RC-I, complete genomehypothetical protein1e-0654.3
NC_011295:1263500:127723612772361277385150Coprothermobacter proteolyticus DSM 5265, complete genomeputative CRISPR-associated protein Cas11e-0654.3