Pre_GI: BLASTP Hits

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Query: NC_011896:781500:799670 Mycobacterium leprae Br4923, complete genome

Start: 799670, End: 799984, Length: 315

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:782000:799661799661799975315Mycobacterium leprae TN, complete genomehypothetical protein2e-55213
NC_018581:3971303:398737939873793987771393Gordonia sp. KTR9 chromosome, complete genomehypothetical protein1e-0652