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Query: NC_011896:563641:563641 Mycobacterium leprae Br4923, complete genome

Start: 563641, End: 564546, Length: 906

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:563500:563632563632564537906Mycobacterium leprae TN, complete genomepossible secreted protein3e-174610
NC_013159:2098500:210881921088192109586768Saccharomonospora viridis DSM 43017, complete genomelysophospholipase L1-like esterase4e-40165
NC_013757:1544348:154561115456111546405795Geodermatophilus obscurus DSM 43160, complete genomelipolytic protein G-D-S-L family7e-30131
NC_013715:1907503:192997419299741930786813Rothia mucilaginosa DY-18, complete genomelysophospholipase L19e-30130
NC_016111:409852:415533415533416336804Streptomyces cattleya NRRL 8057, complete genomehypothetical protein7e-25114
NC_019673:2635585:265162826516282652461834Saccharothrix espanaensis DSM 44229 complete genomeSGNH hydrolase5e-1582