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Query: NC_011896:363448:384350 Mycobacterium leprae Br4923, complete genome

Start: 384350, End: 385666, Length: 1317

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_010612:835648:8616808616808629991320Mycobacterium marinum M, complete genomehypothetical protein0649
NC_019950:481881:5046885046885060071320Mycobacterium canettii CIPT 140060008 complete genomeConserved membrane protein of unknown function0645
NC_009565:479500:5014705014705027891320Mycobacterium tuberculosis F11, complete genomehypothetical protein0645
NC_012207:477500:4994484994485007671320Mycobacterium bovis BCG str. Tokyo 172, complete genomehypothetical protein0645
NC_002945:476835:4993194993195006381320Mycobacterium bovis AF2122/97, complete genomehypothetical protein0645
NC_015848:483500:5086695086695099881320Mycobacterium canettii CIPT 140010059, complete genomehypothetical protein0645
NC_008769:507000:5291155291155304341320Mycobacterium bovis BCG str. Pasteur 1173P2, complete genomehypothetical protein0645
NC_012943:476500:4985594985594998781320Mycobacterium tuberculosis KZN 1435 chromosome, complete genomehypothetical protein0645
NC_016768:476500:4985594985594998781320Mycobacterium tuberculosis KZN 4207 chromosome, complete genomehypothetical protein0645
NC_016804:477500:4994494994495007681320Mycobacterium bovis BCG str. Mexico chromosome, complete genomehypothetical protein0645
NC_000962:475816:4983004983004996191320Mycobacterium tuberculosis H37Rv, complete genomePOSSIBLE CONSERVED MEMBRANE PROTEIN0641
NC_009525:477093:4996104996105009291320Mycobacterium tuberculosis H37Ra, complete genomeputative conserved membrane protein0641
NC_017186:361444:3614443614443628621419Amycolatopsis mediterranei S699 chromosome, complete genomehypothetical protein6e-33142