Pre_GI: BLASTP Hits

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Query: NC_011896:363448:380661 Mycobacterium leprae Br4923, complete genome

Start: 380661, End: 381446, Length: 786

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:363432:380645380645381430786Mycobacterium leprae TN, complete genomethiazole synthase2e-121434
NC_013715:1907503:191410119141011914871771Rothia mucilaginosa DY-18, complete genomeuncharacterized enzyme of thiazole biosynthesis1e-75282
NC_016790:31240:312403124032025786Corynebacterium diphtheriae VA01 chromosome, complete genomethiazole synthase1e-72273
NC_009656:475465:490135490135490932798Pseudomonas aeruginosa PA7 chromosome, complete genomethiazole synthase6e-57220
NC_013894:1194458:119820811982081199011804Thermocrinis albus DSM 14484 chromosome, complete genomethiazole biosynthesis family protein6e-56217
NC_010688:1192410:119334111933411194135795Xanthomonas campestris pv. campestris, complete genomethiazole biosynthesis protein2e-53209
NC_007086:1224867:122772612277261228520795Xanthomonas campestris pv. campestris str. 8004, complete genomethiazole synthase2e-53209
NC_007484:1823751:1824490182449018255331044Nitrosococcus oceani ATCC 19707, complete genomethiazole synthase1e-53209
NC_011901:3363500:338242633824263383220795Thioalkalivibrio sulfidophilus HL-EbGr7 chromosome, completethiazole biosynthesis family protein1e-53209
NC_003902:3666544:373100037310003731794795Xanthomonas campestris pv. campestris str. ATCC 33913, completethiazole synthase2e-53209
NC_015638:1824794:185763718576371858407771Lacinutrix sp. 5H-3-7-4 chromosome, complete genomeThiazole synthase4e-53207
NC_015167:2068607:209512320951232095899777Cellulophaga lytica DSM 7489 chromosome, complete genomeThiazole synthase1e-52206
NC_013939:212331:221993221993222769777Deferribacter desulfuricans SSM1, complete genomethiamine biosynthesis protein ThiG5e-51201
NC_017262:623351:641591641591642586996Zymomonas mobilis subsp. mobilis ATCC 10988 chromosome, completethiamine biosynthesis protein ThiS2e-50198
NC_006347:2899653:291064629106462911422777Bacteroides fragilis YCH46, complete genomethiazole synthase1e-49196
NC_003228:2973266:298426029842602985036777Bacteroides fragilis NCTC 9343, complete genomethiazole synthase1e-49196
NC_005945:754517:757467757467758243777Bacillus anthracis str. Sterne, complete genomethiazole synthase1e-49196
NC_019896:2805098:282963628296362830406771Bacillus subtilis subsp. subtilis str. BSP1 chromosome, completeThiazole biosynthesis protein ThiG2e-49196
NC_020304:2107979:213018321301832130965783Desulfocapsa sulfexigens DSM 10523, complete genomeputative enzyme of thiazole biosynthesis7e-49194
NC_007644:1694879:169651716965171697284768Moorella thermoacetica ATCC 39073, complete genomeThiazole biosynthesis2e-48192
NC_019815:679592:698477698477699280804Candidatus Kinetoplastibacterium crithidii (ex Angomonas deaneithiamine biosynthesis ThiG2e-48192
NC_021171:1689518:170629417062941707061768Bacillus sp. 1NLA3E, complete genomethiazole synthase2e-48192
NC_007963:3500468:350260035026003503400801Chromohalobacter salexigens DSM 3043, complete genomethiazole biosynthesis4e-48191
NC_009465:766893:797828797828798607780Candidatus Vesicomyosocius okutanii HA, complete genomethiazole synthase4e-48191
NC_006513:1379735:138249513824951383280786Azoarcus sp. EbN1, complete genomethiazole synthase5e-48191
NC_014831:2201246:2222243222224322233881146Thermaerobacter marianensis DSM 12885 chromosome, complete genomethiazole-phosphate synthase2e-44179
NC_012881:2878000:289942528994252900201777Desulfovibrio salexigens DSM 2638, complete genomethiazole biosynthesis family protein2e-43176
NC_014828:1632000:163211316321131632898786Ethanoligenens harbinense YUAN-3 chromosome, complete genomethiazole biosynthesis family protein6e-42171
NC_015425:718384:732473732473733237765Clostridium botulinum BKT015925 chromosome, complete genomethiazole biosynthesis family protein9e-42170
NC_003295:112778:126991126991127818828Ralstonia solanacearum GMI1000, complete genomethiazole synthase6e-41167
NC_007503:1111457:112438511243851125149765Carboxydothermus hydrogenoformans Z-2901, complete genomethiamine biosynthesis protein ThiG1e-40166
NC_012026:21385:279142791428708795Anaplasma marginale str. Florida, complete genomethiazole biosynthesis protein (thiG)2e-39162
NC_013216:1748241:176841517684151769206792Desulfotomaculum acetoxidans DSM 771, complete genomethiazole biosynthesis family protein3e-39161
NC_007799:186000:195868195868196650783Ehrlichia chaffeensis str. Arkansas, complete genomethiamin biosynthesis ThiG1e-38160
NC_003454:249304:250434250434251207774Fusobacterium nucleatum subsp. nucleatum ATCC 25586, completethiazole synthase3e-35148
NC_016751:857359:882065882065882832768Marinitoga piezophila KA3 chromosome, complete genomeenzyme of thiazole biosynthesis9e-35147
NC_015389:534000:535151535151535957807Coriobacterium glomerans PW2 chromosome, complete genomethiazole-phosphate synthase8e-34144
NC_011988:924721:929069929069929842774Agrobacterium vitis S4 chromosome 2, complete genomethiamin biosynthesis ThiG2e-33142
NC_020291:5409587:541134754113475412123777Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genomethiazole synthase ThiG3e-32138