Pre_GI: BLASTP Hits

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Query: NC_011896:3252925:11195 Mycobacterium leprae Br4923, complete genome

Start: 11195, End: 12106, Length: 912

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:1:111951119512106912Mycobacterium leprae TN, complete genomehypothetical protein8e-164576
NC_011896:1:111951119512106912Mycobacterium leprae Br4923, complete genomehypothetical protein8e-164576
NC_015564:4727630:102921029210675384Amycolicicoccus subflavus DQS3-9A1 chromosome, complete genomehypothetical protein4e-24112
NC_015312:1:1086110861119641104Pseudonocardia dioxanivorans CB1190 chromosome, complete genomehypothetical protein1e-22107
NC_017186:3694:112781127811943666Amycolatopsis mediterranei S699 chromosome, complete genomehypothetical protein4e-22105
NC_014318:3691:112781127811943666Amycolatopsis mediterranei U32 chromosome, complete genomehypothetical protein4e-22105
NC_013510:1:119611196112698738Thermomonospora curvata DSM 43183, complete genomehypothetical protein2e-1686.3
NC_013521:4240468:113991139912226828Sanguibacter keddieii DSM 10542, complete genomehypothetical protein2e-1376.6
NC_012803:3691:107431074311243501Micrococcus luteus NCTC 2665, complete genomehypothetical protein4e-1168.9
NC_013595:10329633:125331253313180648Streptosporangium roseum DSM 43021, complete genomehypothetical protein4e-1168.9
NC_014830:13179:158871588716534648Intrasporangium calvum DSM 43043 chromosome, complete genomehypothetical protein4e-1168.9
NC_014218:4424:9864986410298435Arcanobacterium haemolyticum DSM 20595 chromosome, complete genomehypothetical protein1e-1067.4
NC_008578:2431074:9582958210040459Acidothermus cellulolyticus 11B, complete genomehypothetical protein2e-1066.6
NC_003888:4251867:425997942599794260536558Streptomyces coelicolor A3(2), complete genomeintegral membrane protein1e-0964.3
NC_007333:3626510:117381173812430693Thermobifida fusca YX, complete genomehypothetical protein1e-0963.9
NC_007333:1:117381173812430693Thermobifida fusca YX, complete genomehypothetical protein1e-0963.9
NC_021177:3997727:401865840186584019254597Streptomyces fulvissimus DSM 40593, complete genomePutative integral membrane protein2e-0963.5
NC_015673:1:113831138312039657Corynebacterium resistens DSM 45100 chromosome, complete genomehypothetical protein3e-0962.4
NC_010545:11950:159471594716531585Corynebacterium urealyticum DSM 7109, complete genomehypothetical protein1e-0757.8
NC_011886:4376261:114621146211848387Arthrobacter chlorophenolicus A6, complete genomeputative integral membrane protein1e-0757.4
NC_015145:4232283:117271172712173447Arthrobacter phenanthrenivorans Sphe3 chromosome, complete genomehypothetical protein1e-0757.4