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Query: NC_011896:2775000:2792957 Mycobacterium leprae Br4923, complete genome

Start: 2792957, End: 2793823, Length: 867

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:2775365:279305927930592793925867Mycobacterium leprae TN, complete genomeprobable antibiotic resistance membrane protein2e-136484
NC_015564:484994:508590508590509420831Amycolicicoccus subflavus DQS3-9A1 chromosome, complete genomedrug resistance ABC transporter ABC transmembrane protein6e-26118
NC_016604:297687:312172312172312915744Mycobacterium rhodesiae NBB3 chromosome, complete genomemultidrug ABC transporter permease1e-1687.4
NC_002944:1285436:129991912999191300659741Mycobacterium avium subsp. paratuberculosis K-10, complete genomeDrrB2e-1480.1
NC_017904:3415700:343457234345723435303732Mycobacterium sp. MOTT36Y chromosome, complete genomeABC transporter efflux protein, DrrB family protein6e-1478.2
NC_016948:3381848:340068634006863401426741Mycobacterium intracellulare MOTT-64 chromosome, complete genomedrrB3e-1375.9
NC_019902:2943719:294371929437192944486768Thioalkalivibrio nitratireducens DSM 14787, complete genomeABC-2 type transporter3e-1169.3
NC_016947:3309898:332908333290833329484402Mycobacterium intracellulare MOTT-02 chromosome, complete genomedrrB7e-0961.2
NC_013510:810525:827241827241828083843Thermomonospora curvata DSM 43183, complete genomeABC-2 type transporter3e-0859.3
NC_013235:5849659:587077358707735871606834Nakamurella multipartita DSM 44233, complete genomeABC-2 type transporter7e-0858.2
NC_013523:959625:962746962746963582837Sphaerobacter thermophilus DSM 20745 chromosome 1, complete genomeABC-2 type transporter2e-0756.2
NC_018524:4988810:499847249984724999356885Nocardiopsis alba ATCC BAA-2165 chromosome, complete genomeABC-2 type transporter family protein4e-0755.5
NC_015671:3211972:322941132294113230238828Cellvibrio gilvus ATCC 13127 chromosome, complete genomeABC transporter1e-0654.3
NC_016593:981500:100753210075321008260729Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completeABC transporter2e-0653.5
NC_019792:3027515:303607230360723036989918Natronobacterium gregoryi SP2 chromosome, complete genomemultidrug ABC transporter permease2e-0653.5
NC_014666:2629799:264607026460702646864795Frankia sp. EuI1c chromosome, complete genomeABC-2 type transporter6e-0651.6