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Query: NC_011896:2775000:2790810 Mycobacterium leprae Br4923, complete genome

Start: 2790810, End: 2792081, Length: 1272

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:2775365:2790912279091227921831272Mycobacterium leprae TN, complete genomeacyltransferase PapA50861
NC_016887:1680338:1700818170081817021611344Nocardia cyriacigeorgica GUH-2, complete genomehypothetical protein3e-32139
NC_014168:2575799:2592289259228925936021314Segniliparus rotundus DSM 44985 chromosome, complete genomehypothetical protein2e-25117
NC_014168:2575799:2590979259097925922861308Segniliparus rotundus DSM 44985 chromosome, complete genomehypothetical protein4e-23109
NC_014168:2575799:2588410258841025896391230Segniliparus rotundus DSM 44985 chromosome, complete genomehypothetical protein3e-20100
NC_014168:2575799:2589651258965125909791329Segniliparus rotundus DSM 44985 chromosome, complete genomehypothetical protein1e-1997.8
NC_018681:7624000:7638267763826776395141248Nocardia brasiliensis ATCC 700358 chromosome, complete genomeacyltransferase PapA51e-1894.7