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Query: NC_011896:2775000:2782673 Mycobacterium leprae Br4923, complete genome

Start: 2782673, End: 2782900, Length: 228

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:2775365:278274827827482782975228Mycobacterium leprae TN, complete genome1e-36151
NC_015161:199666:200690200690201682993Deinococcus proteolyticus MRP chromosome, complete genomeAsparaginase5e-0753.1
NC_012526:157000:174797174797175762966Deinococcus deserti VCD115, complete genomeputative L-asparaginase, (L-asparagine amidohydrolase), (L- ASNase)1e-0652