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Query: NC_011896:2539908:2554670 Mycobacterium leprae Br4923, complete genome

Start: 2554670, End: 2555194, Length: 525

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:2539983:255474525547452555269525Mycobacterium leprae TN, complete genomehypothetical protein2e-76284
NC_014659:1006500:100959910095991010231633Rhodococcus equi 103S, complete genomeresuscitation-promoting factor rpfA1e-33142
NC_018750:3141196:315820031582003158922723Streptomyces venezuelae ATCC 10712, complete genomeputative secreted protein1e-27122
NC_015957:9801884:980739798073979808110714Streptomyces violaceusniger Tu 4113 chromosome, complete genometransglycosylase-like domain-containing protein2e-27121
NC_010545:11950:307723077231110339Corynebacterium urealyticum DSM 7109, complete genomeresuscitation-promoting factor RpfC1e-25115
NC_013172:2647716:2663597266359726648471251Brachybacterium faecium DSM 4810, complete genomehypothetical protein4e-24110
NC_018681:5490963:552535955253595525946588Nocardia brasiliensis ATCC 700358 chromosome, complete genomeresuscitation-promoting factor1e-23109
NC_019673:526000:526094526094527011918Saccharothrix espanaensis DSM 44229 complete genomeTransglycosylase domain protein3e-22104
NC_018750:3141196:3159358315935831604731116Streptomyces venezuelae ATCC 10712, complete genomeputative secreted protein2e-21101
NC_008726:1533727:1545021154502115492504230Mycobacterium vanbaalenii PYR-1, complete genomephage tail tape measure protein, TP901 family2e-2098.6
NC_015957:9801884:9808541980854198095571017Streptomyces violaceusniger Tu 4113 chromosome, complete genometransglycosylase-like domain-containing protein3e-2097.8
NC_010612:4654936:465706346570634657794732Mycobacterium marinum M, complete genomeresuscitation-promoting factor RpfE4e-1787.4
NC_012803:1552122:157546115754611576132672Micrococcus luteus NCTC 2665, complete genomeRpf resuscitation promoting factor with transglycosylase-like domain9e-1579.7
NC_013441:1221472:1229226122922612304371212Gordonia bronchialis DSM 43247, complete genome1e-0962.4