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Query: NC_011896:2539908:2543851 Mycobacterium leprae Br4923, complete genome

Start: 2543851, End: 2545590, Length: 1740

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:2539983:2543926254392625456651740Mycobacterium leprae TN, complete genomepossible membrane protein01068
NC_014659:1006500:1023811102381110254061596Rhodococcus equi 103S, complete genomeMFS transporter3e-136486
NC_019673:526000:5366415366415381641524Saccharothrix espanaensis DSM 44229 complete genomehypothetical protein6e-105381