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Query: NC_011896:2539908:2541910 Mycobacterium leprae Br4923, complete genome

Start: 2541910, End: 2542341, Length: 432

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:2539983:254198525419852542416432Mycobacterium leprae TN, complete genomeputative MarR-family protein9e-68254
NC_019673:526000:546388546388546852465Saccharothrix espanaensis DSM 44229 complete genomeTranscriptional regulator, MarR family2e-24111
NC_014151:813755:835951835951836403453Cellulomonas flavigena DSM 20109 chromosome, complete genometranscriptional regulator, MarR family7e-1785.9
NC_003888:4750489:475082847508284751265438Streptomyces coelicolor A3(2), complete genomemarR-family protein1e-1478.2
NC_016114:2612465:263489826348982635410513Streptomyces flavogriseus ATCC 33331 chromosome, complete genomeregulatory protein MarR9e-1268.9
NC_008536:4921224:493680149368014937217417Solibacter usitatus Ellin6076, complete genometranscriptional regulator, MarR family2e-1168.2
NC_016109:327826:342738342738343184447Kitasatospora setae KM-6054, complete genomeputative MarR family transcriptional regulator5e-0959.7
NC_015856:3675592:369300036930003693458459Collimonas fungivorans Ter331 chromosome, complete genometranscriptional regulator1e-0652