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Query: NC_011896:2539908:2539908 Mycobacterium leprae Br4923, complete genome

Start: 2539908, End: 2540663, Length: 756

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:2539983:253998325399832540738756Mycobacterium leprae TN, complete genomehypothetical protein3e-142504
NC_019673:526000:559821559821560738918Saccharothrix espanaensis DSM 44229 complete genomehypothetical protein5e-59227
NC_014246:1991093:2011606201160620126911086Mobiluncus curtisii ATCC 43063 chromosome, complete genomeDNA-binding protein7e-1684.3