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Query: NC_011896:1:17130 Mycobacterium leprae Br4923, complete genome

Start: 17130, End: 17411, Length: 282

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:1:171341713417415282Mycobacterium leprae TN, complete genomehypothetical protein2e-47187
NC_013757:21245:380783807838350273Geodermatophilus obscurus DSM 43160, complete genomeprotein of unknown function UPF02332e-1271.2
NC_016801:36000:432294322943498270Corynebacterium diphtheriae C7 (beta) chromosome, complete genomeputative septation inhibitor protein4e-1270.1
NC_016790:31240:417804178042049270Corynebacterium diphtheriae VA01 chromosome, complete genomeputative septation inhibitor protein4e-1270.1
NC_016943:21364:383313833138603273Blastococcus saxobsidens DD2, complete genomehypothetical protein8e-1165.9
NC_010545:11950:575365753657814279Corynebacterium urealyticum DSM 7109, complete genomehypothetical protein9e-0855.8
NC_013510:39975:609956099561252258Thermomonospora curvata DSM 43183, complete genomeprotein of unknown function UPF02337e-0752.8