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Query: NC_011896:1716000:1716857 Mycobacterium leprae Br4923, complete genome

Start: 1716857, End: 1717183, Length: 327

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:1716000:171692417169241717250327Mycobacterium leprae TN, complete genomepossible membrane protein4e-54209
NC_013510:5394432:542606854260685426418351Thermomonospora curvata DSM 43183, complete genomehypothetical protein2e-1477.8
NC_002944:1781905:178814617881461788499354Mycobacterium avium subsp. paratuberculosis K-10, complete genomehypothetical protein3e-1270.5