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Query: NC_011896:1380000:1395319 Mycobacterium leprae Br4923, complete genome

Start: 1395319, End: 1396038, Length: 720

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:1380000:139529113952911396010720Mycobacterium leprae TN, complete genomehypothetical protein1e-115415
NC_016787:733685:736654736654737562909Corynebacterium diphtheriae HC03 chromosome, complete genomeputative secreted protein3e-37155
NC_016786:720000:723060723060723968909Corynebacterium diphtheriae HC01 chromosome, complete genomeputative secreted protein4e-37154
NC_016782:720000:723091723091723999909Corynebacterium diphtheriae 241 chromosome, complete genomeputative secreted protein4e-37154
NC_017904:2641270:265216026521602652987828Mycobacterium sp. MOTT36Y chromosome, complete genomehypothetical protein1e-24113
NC_002935:181902:1860591860591874981440Corynebacterium diphtheriae NCTC 13129, complete genomehypothetical protein6e-1891.3