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Query: NC_011896:1380000:1390623 Mycobacterium leprae Br4923, complete genome

Start: 1390623, End: 1390883, Length: 261

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:1380000:139059513905951390855261Mycobacterium leprae TN, complete genomehypothetical protein7e-42168
NC_014666:4043279:404875440487544049623870Frankia sp. EuI1c chromosome, complete genomeregulatory protein GntR HTH2e-1684.3
NC_015656:1876627:188194718819471882705759Frankia symbiont of Datisca glomerata chromosome, complete genomeGntR domain-containing protein6e-1062.8
NC_016947:1311264:133507813350781335860783Mycobacterium intracellulare MOTT-02 chromosome, complete genomeregulatory protein GntR2e-0651.2
NC_008595:2546696:257775925777592578541783Mycobacterium avium 104, complete genomeregulatory protein GntR, HTH2e-0651.2