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Query: NC_011896:1380000:1382354 Mycobacterium leprae Br4923, complete genome

Start: 1382354, End: 1382653, Length: 300

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002677:1380000:138232613823261382625300Mycobacterium leprae TN, complete genomehypothetical protein2e-42171
NC_002677:491043:508327508327508629303Mycobacterium leprae TN, complete genomeputative PE-family protein2e-1064.3
NC_011896:491052:508336508336508638303Mycobacterium leprae Br4923, complete genomeputative PE-family protein7e-1062.8
NC_020133:942375:9423759423759441201746Mycobacterium liflandii 128FXT, complete genomePE-PGRS family protein7e-0959.3
NC_010612:6385520:6388395638839563956937299Mycobacterium marinum M, complete genomePE-PGRS family protein7e-0855.8
NC_017904:3113000:312807631280763128375300Mycobacterium sp. MOTT36Y chromosome, complete genomePE family protein1e-0651.6
NC_017904:4742775:475137047513704751669300Mycobacterium sp. MOTT36Y chromosome, complete genomePE family protein4e-0650.4