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Query: NC_011896:1096500:1108070 Mycobacterium leprae Br4923, complete genome

Start: 1108070, End: 1108209, Length: 140

Host Lineage: Mycobacterium leprae; Mycobacterium; Mycobacteriaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain was isolated from a human skin biopsy in Brazil, and passaged in nude mice and armadillos. The bacterium is a close relative of M. tuberculosis. However, compared to the latter, the genome of M. leprae is smaller due to reductive genome evolution, with many important metabolic activities including siderophore production, part of the oxidative chain, most of the microaerophilic and anaerobic respiratory chains, and numerous catabolic systems and their regulatory circuits eliminated due to extensive recombination events between dispersed repetitive sequences. It is evident that this species has undergone massive genome reduction over time as a result of its parasitic nature, discarding more than half its genes and rendering it the most striking example of genome reduction in a microbial pathogen.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_011896:363448:369489369489369628140Mycobacterium leprae Br4923, complete genome9e-2095.5
NC_002677:363432:369473369473369612140Mycobacterium leprae TN, complete genome9e-2095.5
NC_002677:1096500:110802711080271108166140Mycobacterium leprae TN, complete genome3e-1994