Pre_GI: BLASTP Hits

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Query: NC_011528:1769349:1788279 Coxiella burnetii CbuK_Q154, complete genome

Start: 1788279, End: 1791398, Length: 3120

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii K Q154 was isolated from a patient with endocarditis and contains the plasmid QpRS. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_002971:1545924:1564919156491915680233105Coxiella burnetii RSA 493, complete genomeIcmE protein01697
NC_010117:1633447:1652302165230216554063105Coxiella burnetii RSA 331, complete genomeIcmE protein01696
NC_015416:2864917:2864917286491728677782862Methanosaeta concilii GP-6 chromosome, complete genomepentapeptide repeat-containing protein2e-0862.8
NC_003552:2318374:2330272233027223319541683Methanosarcina acetivorans C2A, complete genomehypothetical protein2e-0862
NC_009925:5794495:581047758104775811361885Acaryochloris marina MBIC11017, complete genomepentapeptide repeat protein1e-0656.2
NC_019964:3028469:3034568303456830364721905Halovivax ruber XH-70, complete genomeputative low-complexity protein3e-0654.7
NC_008576:2710500:26871822687182273193244751Magnetococcus sp. MC-1, complete genomeputative outer membrane adhesin like proteiin3e-0654.7