Pre_GI: BLASTP Hits

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Query: NC_011527:1443076:1443076 Coxiella burnetii CbuG_Q212, complete genome

Start: 1443076, End: 1443975, Length: 900

Host Lineage: Coxiella burnetii; Coxiella; Coxiellaceae; Legionellales; Proteobacteria; Bacteria

General Information: Coxiella burnetii G Q212 was isolated from a case of endocarditis and does not carry a plasmid. This organism is widely distributed in nature and can cause infections in reptiles, birds, and mammals. It causes Q fever, or 'query' fever, an atypical pneumonia first associated with abattoir workers in Australia. Transmission may be through insect vectors such as ticks that have bitten an infected wild or domesticated animal, or through an aerosol produced by domesticated animals such as sheep or cattle. The presence of a plasmid is believed to be associated with virulence and pathogenicity, however C. burnetii isolates containing plasmid QpDG are avirulent in guinea pigs and plasmidless isolates have been associated with endocarditis in humans. Coxiella burnetii has a developmental life cycle, and can grow vegetatively through binary fission, or asymmetrically and produce a spore-like cell. The spore-like cell may enable the organism to exist extracellularly for small amounts of time. This bacterium is an obligate intracellular pathogen. It is endocytosed by a host cell, a macrophage for example, and lives and replicates inside the phagolysozome, a unique property of this organism. The genome encodes proteins that have a higher than average pI, which may enable adaptation to the acidic environment of the phagolysozome. The chromosome also contains genes for a number of detoxification and stress response proteins such as dismutases that allow growth in the oxidative environment. The type IV system is similar to the one found in Legionella, which may be important for intracellular survival. This organism produces numerous ankyrin-repeat proteins that may be involved in interactions with the host cell. The genome has 83 pseudogenes, which may be a result of the typical genome-wide degradation observed with other intracellular organisms and also has a group I intron in the 23S ribosomal RNA gene.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_008260:2992813:3012622301262230136741053Alcanivorax borkumensis SK2, complete genomehydroxymethylglutaryl-CoA lyase2e-49196
NC_014318:1537732:155728815572881558223936Amycolatopsis mediterranei U32 chromosome, complete genomehydroxymethylglutaryl-CoA lyase3e-76285
NC_019771:2783471:2800237280023728014121176Anabaena cylindrica PCC 7122, complete genomehomocitrate synthase3e-0859.7
NC_017192:2505369:2527445252744525284731029Arcobacter sp. L, complete genome4-hydroxy-2-oxovalerate aldolase3e-0859.3
NC_002570:1220180:123086212308621231773912Bacillus halodurans C-125, complete genomehydroxymethylglutaryl-CoA lyase5e-71268
NC_013791:2273389:228100322810032281917915Bacillus pseudofirmus OF4 chromosome, complete genomehydroxymethylglutaryl-CoA lyase1e-81303
NC_013791:579842:5849545849545865011548Bacillus pseudofirmus OF4 chromosome, complete genome2-isopropylmalate synthase3e-0755.8
NC_021171:1689518:169858416985841699501918Bacillus sp. 1NLA3E, complete genomehydroxymethylglutaryl-CoA lyase4e-83308
NC_014098:1258559:127455112745511275459909Bacillus tusciae DSM 2912 chromosome, complete genomepyruvate carboxyltransferase7e-75280
NC_002928:507749:540705540705541652948Bordetella parapertussis 12822, complete genomeputative hydroxymethylglutaryl-CoA lyase1e-55216
NC_015381:4182194:419556941955694196555987Burkholderia gladioli BSR3 chromosome 1, complete sequencepyruvate carboxyltransferase5e-46184
NC_003912:1742370:1767403176740317689381536Campylobacter jejuni RM1221, complete genome2-isopropylmalate synthase1e-0653.9
NC_009707:1811650:1834522183452218360571536Campylobacter jejuni subsp. doylei 269.97 chromosome, complete2-isopropylmalate synthase2e-0653.5
NC_008787:1582110:1606158160615816076931536Campylobacter jejuni subsp. jejuni 81-176, complete genome2-isopropylmalate synthase2e-0653.1
NC_017279:1603916:1627787162778716293221536Campylobacter jejuni subsp. jejuni IA3902 chromosome, complete2-isopropylmalate synthase1e-0654.3
NC_014802:1631483:1654382165438216559171536Campylobacter jejuni subsp. jejuni ICDCCJ07001 chromosome, complete2-isopropylmalate synthase2e-0653.5
NC_017280:1584961:1609338160933816108731536Campylobacter jejuni subsp. jejuni M1 chromosome, complete genome2-isopropylmalate synthase3e-0652.4
NC_002163:1607360:1630393163039316319281536Campylobacter jejuni subsp. jejuni NCTC 11168, complete genome2-isopropylmalate synthase1e-0653.9
NC_017281:1645903:1670936167093616724711536Campylobacter jejuni subsp. jejuni S3 chromosome, complete genome2-isopropylmalate synthase1e-0653.9
NC_011565:665515:6718096718096729331125Candidatus Azobacteroides pseudotrichonymphae genomovar. CFP2,homocitrate synthase3e-0652.8
NC_013132:3605317:360783636078363608681846Chitinophaga pinensis DSM 2588, complete genomeHydroxymethylglutaryl-CoA lyase2e-26120
NC_010175:448020:470049470049470990942Chloroflexus aurantiacus J-10-fl, complete genomepyruvate carboxyltransferase3e-53208
NC_010175:398453:4192794192794204061128Chloroflexus aurantiacus J-10-fl, complete genomepyruvate carboxyltransferase2e-0756.6
NC_012032:398419:4194204194204205471128Chloroflexus sp. Y-400-fl, complete genomepyruvate carboxyltransferase2e-0756.6
NC_012032:448161:470191470191471132942Chloroflexus sp. Y-400-fl, complete genomepyruvate carboxyltransferase3e-53208
NC_003030:3301342:3309512330951233111551644Clostridium acetobutylicum ATCC 824, complete genome2-isopropylmalate synthase1e-0757.8
NC_015687:3302372:3311139331113933127821644Clostridium acetobutylicum DSM 1731 chromosome, complete genomeputative alpha-isopropylmalate/homocitrate synthase family transferase1e-0757.8
NC_017295:3300500:3308769330876933104121644Clostridium acetobutylicum EA 2018 chromosome, complete genomeputative alpha-isopropylmalate/homocitrate synthase family transferase1e-0757.8
NC_009617:68779:8997389973911421170Clostridium beijerinckii NCIMB 8052 chromosome, complete genometrans-homoaconitate synthase2e-0860.5
NC_011898:3973627:3997446399744639989721527Clostridium cellulolyticum H10, complete genome2-isopropylmalate synthase6e-1375.1
NC_009089:965959:968115968115969011897Clostridium difficile 630, complete genomeputative hydroxymethylglutaryl-CoA lyase5e-51201
NC_017179:905347:907504907504908400897Clostridium difficile BI1, complete genomeputative hydroxymethylglutaryl-CoA lyase2e-51202
NC_013315:895500:897727897727898623897Clostridium difficile CD196 chromosome, complete genomehydroxymethylglutaryl-CoA lyase2e-51202
NC_013316:891782:895342895342896238897Clostridium difficile R20291, complete genomeputative hydroxymethylglutaryl-CoA lyase2e-51202
NC_020291:79502:8921589215903811167Clostridium saccharoperbutylacetonicum N1-4(HMT), complete genome2-isopropylmalate synthase 27e-0754.7
NC_013446:3520500:353669135366913537584894Comamonas testosteroni CNB-2, complete genomepyruvate carboxyltransferase2e-89329
NC_020302:146807:164963164963165919957Corynebacterium halotolerans YIM 70093 = DSM 44683, completehydroxymethylglutaryl-CoA lyase9e-29127
NC_011528:1282691:128269112826911283590900Coxiella burnetii CbuK_Q154, complete genomehydroxymethylglutaryl-CoA lyase3e-175614
NC_009727:1542000:154394015439401544839900Coxiella burnetii Dugway 7E9-12, complete genomehydroxymethylglutaryl-CoA lyase1e-175615
NC_015723:589727:591846591846592799954Cupriavidus necator N-1 chromosome 2, complete sequencehydroxymethylglutaryl-CoA lyase YngG7e-47187
NC_015727:1050500:105631110563111056805495Cupriavidus necator N-1 plasmid BB1p, complete sequence2e-2099.8
NC_010546:553774:5574135574135585461134Cyanothece sp. ATCC 51142 chromosome circular, complete sequencehomocitrate synthase4e-0652.4
NC_018697:505915:5210545210545220791026Cycloclasticus sp. P1 chromosome, complete genome4-hydroxy-2-oxovalerate aldolase NahM3e-0756.2
NC_013939:1688400:1693524169352416950741551Deferribacter desulfuricans SSM1, complete genome2-isopropylmalate synthase3e-0756.2
NC_018867:993903:1012972101297210145071536Dehalobacter sp. CF chromosome, complete genome2-isopropylmalate synthase2e-0653.1
NC_021184:569653:5876865876865892151530Desulfotomaculum gibsoniae DSM 7213, complete genome2-isopropylmalate synthase, bacterial type3e-0962.8
NC_015573:1671000:1673841167384116750071167Desulfotomaculum kuznetsovii DSM 6115 chromosome, complete genomehomocitrate synthase4e-0755.8
NC_014836:312353:3321473321473337211575Desulfurispirillum indicum S5 chromosome, complete genome2-isopropylmalate synthase7e-0651.6
NC_015185:174847:1786051786051801521548Desulfurobacterium thermolithotrophum DSM 11699 chromosome,2-isopropylmalate synthase6e-0651.6
NC_013508:2130681:214523821452382146176939Edwardsiella tarda EIB202, complete genomeputative hydroxymethylglutaryl-CoA lyase1e-51203
NC_009921:4399000:440358844035884404478891Frankia sp. EAN1pec, complete genomepyruvate carboxyltransferase4e-61235
NC_020210:661236:670371670371671270900Geobacillus sp. GHH01, complete genomehydroxymethylglutaryl-CoA lyase1e-64246
NC_014916:22644:293372933730221885Geobacillus sp. Y412MC52 plasmid pGYMC5201, complete sequencepyruvate carboxyltransferase7e-55214
NC_013412:33834:145414542338885Geobacillus sp. Y412MC61 plasmid pGYMC6101, complete sequencepyruvate carboxyltransferase7e-55214
NC_016593:762216:788713788713789612900Geobacillus thermoleovorans CCB_US3_UF5 chromosome, completepyruvate carboxyltransferase1e-66253
NC_016906:3666358:366862836686283669533906Gordonia polyisoprenivorans VH2 chromosome, complete genomehydroxymethylglutaryl-CoA lyase YngG7e-46184
NC_019978:224619:2454822454822469841503Halobacteroides halobius DSM 5150, complete genome2-isopropylmalate synthase, bacterial type8e-0651.2
NC_013967:1375255:1377383137738313787051323Haloferax volcanii DS2 chromosome, complete genome2-isopropylmalate synthase3e-0859.3
NC_015318:706374:7109427109427124591518Hippea maritima DSM 10411 chromosome, complete genome2-isopropylmalate synthase7e-0651.6
NC_012982:1569426:158914515891451590107963Hirschia baltica ATCC 49814, complete genomepyruvate carboxyltransferase6e-46184
NC_017161:1012874:102925410292541030231978Hydrogenobacter thermophilus TK-6 chromosome, complete genomepyruvate carboxyltransferase2e-0653.1
NC_013799:1012884:102926410292641030241978Hydrogenobacter thermophilus TK-6, complete genomehomocitrate synthase2e-0653.1
NC_015557:1333158:1343290134329013452061917Hydrogenobaculum sp. 3684 chromosome, complete genomePyruvate carboxylase8e-0857.8
NC_020411:1333352:1343484134348413454001917Hydrogenobaculum sp. HO, complete genomeConserved carboxylase region8e-0857.8
NC_011126:1345984:1353258135325813551741917Hydrogenobaculum sp. Y04AAS1, complete genomeOxaloacetate decarboxylase4e-0755.8
NC_014632:1248611:1262476126247612639901515Ilyobacter polytropus DSM 2926 chromosome, complete genome2-isopropylmalate synthase2e-0860.1
NC_007802:1093785:111099111109911111845855Jannaschia sp. CCS1, complete genomeHydroxymethylglutaryl-CoA lyase5e-73274
NC_014655:3345204:335046833504683351310843Leadbetterella byssophila DSM 17132 chromosome, complete genomehydroxymethylglutaryl-CoA lyase6e-32138
NC_013192:1824174:1828147182814718296581512Leptotrichia buccalis DSM 1135, complete genome2-isopropylmalate synthase8e-0651.2
NC_007626:697926:722387722387723280894Magnetospirillum magneticum AMB-1, complete genomeIsopropylmalate/homocitrate/citramalate synthase3e-106385
NC_015216:2113556:2114881211488121160561176Methanobacterium sp. AL-21 chromosome, complete genomeisopropylmalate/citramalate/homocitrate synthase1e-1067.8
NC_013156:127000:1361131361131375881476Methanocaldococcus fervens AG86, complete genomeisopropylmalate/citramalate/homocitrate synthase6e-0755.1
NC_013156:226215:2383302383302398861557Methanocaldococcus fervens AG86, complete genomeisopropylmalate/citramalate/homocitrate synthase3e-1066.2
NC_014122:393856:4129364129364144711536Methanocaldococcus infernus ME chromosome, complete genomeisopropylmalate/citramalate/homocitrate synthase9e-0857.8
NC_000909:1123161:1137352113735211389081557Methanocaldococcus jannaschii DSM 2661, complete genome2-isopropylmalate synthase2e-0859.7
NC_013887:812091:8258038258038273591557Methanocaldococcus sp. FS406-22 chromosome, complete genomeisopropylmalate/citramalate/homocitrate synthase6e-0961.6
NC_013887:245236:2600382600382615131476Methanocaldococcus sp. FS406-22 chromosome, complete genomeisopropylmalate/citramalate/homocitrate synthase1e-0653.9
NC_018876:2760000:2776832277683227780041173Methanolobus psychrophilus R15 chromosome, complete genome2-isopropylmalate synthase4e-0652.4
NC_014507:2479221:2488851248885124899751125Methanoplanus petrolearius DSM 11571 chromosome, complete genomepyruvate carboxyltransferase5e-0755.1
NC_015416:2113949:2131405213140521329611557Methanosaeta concilii GP-6 chromosome, complete genome(R)-citramalate synthase2e-0756.2
NC_007681:218921:2445282445282460271500Methanosphaera stadtmanae DSM 3091, complete genomeLeuA12e-0653.5
NC_007796:2607240:2612459261245926138981440Methanospirillum hungatei JF-1, complete genomepyruvate carboxyltransferase4e-0755.8
NC_015636:1477221:1501063150106315025381476Methanothermococcus okinawensis IH1 chromosome, complete genomeisopropylmalate/citramalate/homocitrate synthase3e-0756.2
NC_010511:1351000:135147713514771352394918Methylobacterium sp. 4-46 chromosome, complete genomepyruvate carboxyltransferase6e-58224
NC_010085:1174917:1183825118382511850061182Nitrosopumilus maritimus SCM1, complete genomepyruvate carboxyltransferase5e-1065.5
NC_009512:5632591:565196556519655652900936Pseudomonas putida F1, complete genomepyruvate carboxyltransferase1e-54213
NC_015458:2338437:233750223375022338440939Pusillimonas sp. T7-7 chromosome, complete genomehydroxymethylglutaryl-CoA lyase7e-34144
NC_000868:1299027:1305441130544113069011461Pyrococcus abyssi GE5, complete genome2-isopropylmalate synthase8e-0754.7
NC_000868:416958:4196564196564207411086Pyrococcus abyssi GE5, complete genome2-isopropylmalate synthase8e-0858.2
NC_003413:893960:9010549010549025531500Pyrococcus furiosus DSM 3638, complete genome2-isopropylmalate synthase8e-0754.7
NC_000961:1481685:1514960151496015160451086Pyrococcus horikoshii OT3, complete genome2-isopropylmalate synthase3e-0756.2
NC_005296:2860000:288100028810002881905906Rhodopseudomonas palustris CGA009, complete genome3-hydroxy-3-methylglutaryl-CoA lyase2e-82305
NC_014738:1507641:150908415090841509932849Riemerella anatipestifer ATCC 11845 = DSM 15868 chromosome,hydroxymethylglutaryl-CoA lyase7e-36150
NC_020125:194691:218941218941219759819Riemerella anatipestifer RA-CH-2, complete genomehypothetical protein2e-33143
NC_008148:1711679:172169517216951722588894Rubrobacter xylanophilus DSM 9941, complete genomepyruvate carboxyltransferase4e-54211
NC_011149:779903:7938077938077955761770Salmonella enterica subsp. enterica serovar Agona str. SL483,oxaloacetate decarboxylase alpha subunit3e-0652.8
NC_006905:848000:8587698587698605441776Salmonella enterica subsp. enterica serovar Choleraesuis stroxaloacetate decarboxylase8e-0651.2
NC_011205:839425:8543158543158560871773Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853oxaloacetate decarboxylase8e-0651.2
NC_011083:862901:8783688783688801371770Salmonella enterica subsp. enterica serovar Heidelberg str. SL476,oxaloacetate decarboxylase alpha subunit5e-0652
NC_010102:2287934:2292299229229922940681770Salmonella enterica subsp. enterica serovar Paratyphi B str. SPB7,hypothetical protein9e-0651.2
NC_016810:819489:8293858293858311601776Salmonella enterica subsp. enterica serovar Typhimurium stroxaloacetate decarboxylase subunit alpha8e-0651.2
NC_016860:857500:8689598689598707341776Salmonella enterica subsp. enterica serovar Typhimurium stroxaloacetate decarboxylase8e-0651.2
NC_016856:819482:8304718304718322461776Salmonella enterica subsp. enterica serovar Typhimurium str. 14028S5e-0652
NC_017046:819414:8293708293708311451776Salmonella enterica subsp. enterica serovar Typhimurium str. 798oxaloacetate decarboxylase subunit alpha9e-0651.2
NC_016857:819429:8293858293858311601776Salmonella enterica subsp. enterica serovar Typhimurium str. ST4/74pyruvate carboxylase subunit B8e-0651.2
NC_008700:1627401:164666716466671647557891Shewanella amazonensis SB2B, complete genomepyruvate carboxyltransferase2e-105382
NC_016633:1130705:1141233114123311428491617Sphaerochaeta pleomorpha str. Grapes chromosome, complete genome2-isopropylmalate synthase, bacterial type7e-0651.6
NC_014623:5181000:518327651832765184253978Stigmatella aurantiaca DW4/3-1 chromosome, complete genomepyruvate carboxyltransferase6e-79294
NC_007181:1094422:1111101111110111125071407Sulfolobus acidocaldarius DSM 639, complete genome2-isopropylmalate synthase1e-1273.9
NC_017275:1189162:1201385120138512027701386Sulfolobus islandicus HVE10/4 chromosome, complete genomeAsnC family transcriptional regulator4e-1168.9
NC_012589:1241782:1254018125401812554031386Sulfolobus islandicus L.S.2.15, complete genomehomocitrate synthase4e-1168.9
NC_012632:1249334:1264638126463812660231386Sulfolobus islandicus M.16.27 chromosome, complete genome2-isopropylmalate synthase4e-1168.9
NC_017276:1051707:1065781106578110671661386Sulfolobus islandicus REY15A chromosome, complete genomeAsnC family transcriptional regulator4e-1168.9
NC_012623:1405893:1410075141007514114601386Sulfolobus islandicus Y.N.15.51 chromosome, complete genome2-isopropylmalate synthase4e-1168.9
NC_002754:824180:8355858355858369701386Sulfolobus solfataricus P2, complete genome2-isopropylmalate synthase1e-0757.4
NC_015958:11511:1704517045182411197Thermoanaerobacter wiegelii Rt8.B1 chromosome, complete genomepyruvate carboxyltransferase2e-0860.1
NC_019970:2263427:2268513226851322696641152Thermoanaerobacterium thermosaccharolyticum M0795, complete genomehomocitrate synthase NifV9e-0857.8
NC_015555:4478:1411214112153051194Thermoanaerobacterium xylanolyticum LX-11 chromosome, complete2-isopropylmalate synthase1e-0551.2
NC_015555:1989463:1996596199659619977471152Thermoanaerobacterium xylanolyticum LX-11 chromosome, completehomocitrate synthase7e-0755.1
NC_013526:911909:9460589460589472331176Thermobaculum terrenum ATCC BAA-798 chromosome 2, complete genomehomocitrate synthase1e-0757.4
NC_011961:528837:538904538904539809906Thermomicrobium roseum DSM 5159 plasmid unnamed, complete sequencehydroxymethylglutaryl-CoA lyase, (HMG-CoA lyase) (HL) (3-hydroxy-3-methylglutarate-CoA lyase)2e-77288
NC_013642:323799:3353613353613369021542Thermotoga naphthophila RKU-10, complete genome2-isopropylmalate synthase3e-0652.8
NC_016148:1877711:191195819119581912878921Thermovirga lienii DSM 17291 chromosome, complete genomepyruvate carboxyltransferase2e-53209
NC_005835:823187:8253088253088268701563Thermus thermophilus HB27, complete genome2-isopropylmalate synthase7e-0858.2
NC_014221:3175013:319765031976503198549900Truepera radiovictrix DSM 17093 chromosome, complete genomeHydroxymethylglutaryl-CoA lyase2e-23109
NC_017270:2500815:2500815250081525023651551Vibrio cholerae LMA3984-4 chromosome chromosome I, complete2-isopropylmalate synthase2e-0653.5
NC_014537:663216:6668936668936680261134Vulcanisaeta distributa DSM 14429 chromosome, complete genomeisopropylmalate/citramalate/homocitratesynthase2e-0860.1