Pre_GI: BLASTN Hits

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Query: NC_011498:1571840 Helicobacter pylori P12, complete genome

Start: 1571840, End: 1590848, Length: 19009

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori P12 is a clinical isolate obtained from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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Islands with an asterisk (*) contain ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

Subject IslandStartEndLengthSubject Host DescriptionE-valueBit scoreVisual BLASTNVisual BLASTP
NC_000915:15839671583967160577621810Helicobacter pylori 26695, complete genome03739BLASTN svgBLASTP svg
NC_000921:10075191007519105809950581Helicobacter pylori J99, complete genome4e-94353BLASTN svgBLASTP svg
NC_011498:44800044800048978841789Helicobacter pylori P12, complete genome2e-77297BLASTN svgBLASTP svg
NC_003912:30265*302655431024046Campylobacter jejuni RM1221, complete genome1e-23119BLASTN svgBLASTP svg
NC_012039:1399699*1399699142559925901Campylobacter lari RM2100, complete genome7e-22113BLASTN svgBLASTP svg
NC_014802:27857*278575874230886Campylobacter jejuni subsp. jejuni ICDCCJ07001 chromosome, complete7e-19103BLASTN svgBLASTP svg
NC_009839:30409*304095668526277Campylobacter jejuni subsp. jejuni 81116, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_002163:29726*297265531925594Campylobacter jejuni subsp. jejuni NCTC 11168, complete genome4e-1487.7BLASTN svgBLASTP svg
NC_008787:31999*319995922327225Campylobacter jejuni subsp. jejuni 81-176, complete genome1e-1179.8BLASTN svgBLASTP svg
NC_015160:26646132664613268809923487Odoribacter splanchnicus DSM 20712 chromosome, complete genome9e-0969.9BLASTN svgBLASTP svg
NC_009922:24874922487492251068223191Alkaliphilus oremlandii OhILAs, complete genome2e-0661.9BLASTN svgBLASTP svg