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Query: NC_011498:448000:478679 Helicobacter pylori P12, complete genome

Start: 478679, End: 479134, Length: 456

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori P12 is a clinical isolate obtained from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.

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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017379:1035464:104604610460461046501456Helicobacter pylori Puno135 chromosome, complete genomehypothetical protein5e-81299
NC_014555:1526775:155070515507051551160456Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein7e-81298
NC_017381:982216:995944995944996399456Helicobacter pylori 2018 chromosome, complete genomehypothetical protein2e-80296
NC_017374:974279:987989987989988444456Helicobacter pylori 2017 chromosome, complete genomehypothetical protein2e-80296
NC_017357:973392:987102987102987557456Helicobacter pylori 908 chromosome, complete genomehypothetical protein2e-80296
NC_017371:1030148:104237910423791042834456Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein3e-80296
NC_017376:57500:867108671087165456Helicobacter pylori SNT49 chromosome, complete genomehypothetical protein3e-80296
NC_014256:448710:465862465862466317456Helicobacter pylori B8 chromosome, complete genomehypothetical protein6e-80295
NC_011333:1040192:105917510591751059630456Helicobacter pylori G27 chromosome, complete genomehypothetical protein2e-79294
NC_010698:870312:899935899935900390456Helicobacter pylori Shi470, complete genomehypothetical protein9e-79291
NC_017367:278916:297779297779298234456Helicobacter pylori F57, complete genomehypothetical protein3e-78289
NC_017361:930280:959853959853960308456Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein4e-78289
NC_017358:220900:241303241303241731429Helicobacter pylori Cuz20 chromosome, complete genomehypothetical protein2e-66250
NC_017361:1528239:154306915430691543542474Helicobacter pylori SouthAfrica7 chromosome, complete genomehypothetical protein1e-0858.5