Pre_GI: BLASTP Hits

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Query: NC_011498:448000:448002 Helicobacter pylori P12, complete genome

Start: 448002, End: 449183, Length: 1182

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori P12 is a clinical isolate obtained from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_015847:808931:8238188238188250741257Methanococcus maripaludis XI chromosome, complete genomerestriction modification system DNA specificity domain-containing protein3e-24113
NC_015578:3495034:3501621350162135027361116Treponema primitia ZAS-2 chromosome, complete genometype I restriction-modification system S subunit4e-22105
NC_006510:372826:3786463786463796861041Geobacillus kaustophilus HTA426, complete genometype I restriction-modification system S subunit2e-21103
NC_015856:1:1045910459117301272Collimonas fungivorans Ter331 chromosome, complete genomerestriction modification system DNA specificity domain-containing protein3e-2099.8
NC_006510:1400000:1406089140608914072641176Geobacillus kaustophilus HTA426, complete genometype I restriction-modification system specificity protein2e-1893.6
NC_015634:3017564:3034052303405230353621311Bacillus coagulans 2-6 chromosome, complete genomeputative type I restriction modification system, specificity protein2e-1790.9
NC_002946:684728:6934166934166946181203Neisseria gonorrhoeae FA 1090, complete genomehypothetical protein2e-1687
NC_011035:968569:9786019786019798031203Neisseria gonorrhoeae NCCP11945 chromosome, complete genomehypothetical protein2e-1687
NC_017511:884083:8946908946908958921203Neisseria gonorrhoeae TCDC-NG08107 chromosome, complete genomehypothetical protein2e-1687
NC_009725:692237:7010037010037022291227Bacillus amyloliquefaciens FZB42, complete genomehypothetical protein1e-1584.7
NC_010163:614634:6229006229006241591260Acholeplasma laidlawii PG-8A chromosome, complete genometype I site-specific restriction-modification system, S (specificity) subunit2e-1584
NC_010175:2488000:2494129249412924954451317Chloroflexus aurantiacus J-10-fl, complete genomerestriction modification system DNA specificity domain3e-1583.2
NC_012793:1718000:1721130172113017224161287Geobacillus sp. WCH70, complete genomerestriction modification system DNA specificity domain protein5e-1479.3
NC_011884:3099488:3118941311894131201791239Cyanothece sp. PCC 7425, complete genomerestriction modification system DNA specificity domain protein9e-1478.2
NC_015676:1530000:1544290154429015455401251Methanosalsum zhilinae DSM 4017 chromosome, complete genomerestriction modification system DNA specificity domain-containing protein9e-1478.2
NC_007759:2097734:2114849211484921160631215Syntrophus aciditrophicus SB, complete genometype I restriction-modification system specificity subunit4e-1376.3
NC_012796:1645856:1674407167440716756901284Desulfovibrio magneticus RS-1, complete genometype I restriction enzyme S protein6e-1375.5
NC_015320:1690047:1699124169912417003861263Archaeoglobus veneficus SNP6 chromosome, complete genomerestriction modification system DNA specificity domain-containing protein8e-1375.1
NC_013411:284461:2934562934562947451290Geobacillus sp. Y412MC61, complete genomerestriction modification system DNA specificity domain protein1e-1274.7
NC_014915:2427000:2444743244474324460321290Geobacillus sp. Y412MC52 chromosome, complete genomerestriction modification system DNA specificity domain protein1e-1274.7
NC_012668:160357:1702231702231714971275Vibrio cholerae MJ-1236 chromosome 1, complete sequencehypothetical protein1e-1274.3
NC_012668:1623350:1640973164097316422471275Vibrio cholerae MJ-1236 chromosome 1, complete sequencehypothetical protein1e-1274.3
NC_012668:2258854:2277744227774422790181275Vibrio cholerae MJ-1236 chromosome 1, complete sequencehypothetical protein1e-1274.3
NC_018867:1407163:1443303144330314445141212Dehalobacter sp. CF chromosome, complete genomeType I restriction-modification system, specificity subunit S5e-1272.4
NC_011831:2213306:2212048221204822133191272Chloroflexus aggregans DSM 9485, complete genomerestriction modification system DNA specificity domain protein6e-1272
NC_012491:743883:7529087529087541431236Brevibacillus brevis NBRC 100599, complete genomeputative type I restriction modification system specificity protein1e-1171.2
NC_014727:995480:1006396100639610075681173Lactobacillus delbrueckii subsp. bulgaricus ND02 chromosome,type-i specificity determinant subunit6e-1168.9
NC_018721:943801:9501419501419514091269Psychroflexus torquis ATCC 700755 chromosome, complete genometype I restriction-modification system, specificity subunit HdsS1e-1067.8
NC_012881:3004784:3009162300916230104091248Desulfovibrio salexigens DSM 2638, complete genomerestriction modification system DNA specificity domain protein4e-1066.2
NC_011662:1:7271727184071137Thauera sp. MZ1T, complete genomerestriction modification system DNA specificity domain protein7e-1065.5
NC_014011:472650:4809384809384821071170Aminobacterium colombiense DSM 12261 chromosome, complete genomerestriction modification system DNA specificity domain protein2e-0963.9
NC_014973:3414459:3431795343179534330301236Geobacter sp. M18 chromosome, complete genomerestriction modification system DNA specificity domain-containing protein3e-0963.2
NC_017362:1512959:151617515161751516576402Helicobacter pylori Lithuania75 chromosome, complete genomeputative type I restriction enzyme specificity protein4e-0962.8
NC_015660:1918307:1937843193784319390361194Geobacillus thermoglucosidasius C56-YS93 chromosome, completerestriction modification system DNA specificity domain-containing protein5e-0962.4
NC_008340:2034810:2045005204500520462641260Alkalilimnicola ehrlichei MLHE-1, complete genomerestriction modification system DNA specificity domain8e-0962
NC_009634:299327:3072993072993085221224Methanococcus vannielii SB chromosome, complete genomerestriction modification system DNA specificity subunit8e-0962
NC_008322:2077628:2102612210261221039581347Shewanella sp. MR-7, complete genomerestriction modification system DNA specificity domain9e-0961.6
NC_007969:2885249:2901693290169329029341242Psychrobacter cryohalolentis K5, complete genomerestriction modification system DNA specificity domain1e-0861.6
NC_013943:2705983:2714857271485727160741218Denitrovibrio acetiphilus DSM 12809 chromosome, complete genomerestriction modification system DNA specificity domain-containing protein2e-0860.8
NC_014220:1162948:1167996116799611692641269Syntrophothermus lipocalidus DSM 12680 chromosome, complete genomerestriction modification system DNA specificity domain protein2e-0860.1
NC_020210:1275031:1285198128519812864541257Geobacillus sp. GHH01, complete genomerestriction modification system DNA specificity domain containing protein5e-0859.3
NC_011185:37922:4654046540478201281Vibrio fischeri MJ11 plasmid pMJ100, complete sequencerestriction modification system S subunit5e-0858.9
NC_011601:4856717:4865866486586648670921227Escherichia coli O127:H6 str. E2348/69 chromosome, complete genometype I restriction-modification enzyme S subunit6e-0858.9
NC_015578:1430112:1445653144565314468701218Treponema primitia ZAS-2 chromosome, complete genomerestriction modification system DNA specificity domain-containing protein8e-0858.5
NC_007298:1418500:141851114185111419368858Dechloromonas aromatica RCB, complete genomeRestriction modification system DNA specificity domain2e-0757.8
NC_007677:1354500:1382294138229413835201227Salinibacter ruber DSM 13855, complete genometype I restriction-modification system, S subunit, putative3e-0757
NC_016838:85487:9616296162973581197Klebsiella pneumoniae subsp. pneumoniae HS11286 plasmid pKPHS1,Restriction modification system DNA specificity domain protein4e-0756.2
NC_014034:1036652:1048875104887510505001626Rhodobacter capsulatus SB1003 chromosome, complete genometype I restriction-modification system RcaSBIP subunit S8e-0755.1
NC_013967:2103968:2130371213037121316031233Haloferax volcanii DS2 chromosome, complete genometype I restriction-modification system specificity subunit1e-0654.7
NC_015696:285456:2951282951282962971170Francisella sp. TX077308 chromosome, complete genometype I restriction-modification system, specificity subunit S1e-0654.7
NC_008942:815280:8215758215758229151341Methanocorpusculum labreanum Z, complete genomehypothetical protein1e-0654.7
NC_013410:1651000:1662625166262516638511227Fibrobacter succinogenes subsp. succinogenes S85 chromosome,restriction modification system DNA specificity domain-containing protein4e-0652.8
NC_014315:1396990:1412173141217314136661494Nitrosococcus watsoni C-113 chromosome, complete genomerestriction modification system DNA specificity domain-containing protein6e-0652.4