Pre_GI: BLASTP Hits

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Query: NC_011498:1571840:1589464 Helicobacter pylori P12, complete genome

Start: 1589464, End: 1590099, Length: 636

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori P12 is a clinical isolate obtained from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_017367:1505780:152467315246731525308636Helicobacter pylori F57, complete genomehypothetical protein3e-120430
NC_017365:1466500:148574314857431486378636Helicobacter pylori F30, complete genomehypothetical protein4e-120430
NC_018939:1583653:160441516044151605050636Helicobacter pylori 26695 chromosome, complete genomehypothetical protein2e-119427
NC_000915:1583967:160439216043921605027636Helicobacter pylori 26695, complete genomehypothetical protein2e-119427
NC_014555:1477934:149406814940681494703636Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein2e-118424
NC_017371:1601452:162200016220001622635636Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein6e-118422
NC_017378:1489818:151015415101541510789636Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein3e-117420
NC_017354:1465925:148205514820551482690636Helicobacter pylori 52 chromosome, complete genomehypothetical protein1e-116418