Pre_GI: BLASTP Hits

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Query: NC_011498:1571840:1589113 Helicobacter pylori P12, complete genome

Start: 1589113, End: 1589460, Length: 348

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori P12 is a clinical isolate obtained from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_018939:1583653:160406416040641604411348Helicobacter pylori 26695 chromosome, complete genomehypothetical protein1e-33141
NC_000915:1583967:160404116040411604388348Helicobacter pylori 26695, complete genomehypothetical protein1e-33141
NC_017354:1465925:148170414817041482051348Helicobacter pylori 52 chromosome, complete genomehypothetical protein8e-35145
NC_017365:1466500:148538614853861485739354Helicobacter pylori F30, complete genomehypothetical protein1e-2098.2
NC_017367:1505780:152431615243161524669354Helicobacter pylori F57, complete genomehypothetical protein5e-1993.2
NC_017371:1601452:162165816216581621996339Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein8e-29125
NC_014555:1477934:149371714937171494064348Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein2e-32137
NC_017378:1489818:150979715097971510150354Helicobacter pylori Puno120 chromosome, complete genomehypothetical protein2e-28124