Pre_GI: BLASTP Hits

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Query: NC_011498:1571840:1580020 Helicobacter pylori P12, complete genome

Start: 1580020, End: 1582023, Length: 2004

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori P12 is a clinical isolate obtained from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014555:1477934:1484566148456614867492184Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein01119
NC_017354:1465925:1472549147254914746992151Helicobacter pylori 52 chromosome, complete genomeputative cytoplasmic protein01021
NC_017365:1466500:1476317147631714784552139Helicobacter pylori F30, complete genomehypothetical protein01013
NC_017367:1505780:1515283151528315174362154Helicobacter pylori F57, complete genomehypothetical protein0989
NC_000915:1583967:1595770159577015970621293Helicobacter pylori 26695, complete genomehypothetical protein0730
NC_017279:29737:5000150001521272127Campylobacter jejuni subsp. jejuni IA3902 chromosome, completeputative cytoplasmic protein4e-152538
NC_007759:2097734:2116066211606621182132148Syntrophus aciditrophicus SB, complete genomehypothetical cytosolic protein1e-112407
NC_017375:1498000:1502519150251915036851167Helicobacter pylori 83 chromosome, complete genomehypothetical protein1e-93344
NC_012440:1215838:1226727122672712289462220Persephonella marina EX-H1, complete genomemacrophage infection protein, MimD5e-88325
NC_014507:374359:3935943935943957952202Methanoplanus petrolearius DSM 11571 chromosome, complete genomeputative cytoplasmic protein8e-87322
NC_013890:191616:2130562130562152212166Dehalococcoides sp. GT chromosome, complete genomehypothetical protein3e-86320
NC_015593:2103815:2112987211298721151642178Sphingobium chlorophenolicum L-1 chromosome chromosome 1, completehypothetical protein1e-85317
NC_000915:1583967:159490815949081595660753Helicobacter pylori 26695, complete genomehypothetical protein4e-85316
NC_009077:4810379:4822291482229148244772187Mycobacterium sp. JLS, complete genomeconserved hypothetical cytosolic protein3e-79296
NC_012673:2535427:2535427253542725376942268Exiguobacterium sp. AT1b, complete genomeputative cytoplasmic protein2e-62241
NC_015601:726962:7361827361827383652184Erysipelothrix rhusiopathiae str. Fujisawa, complete genomehypothetical protein5e-41169
NC_017375:1498000:150208615020861502544459Helicobacter pylori 83 chromosome, complete genomehypothetical protein2e-29131