Pre_GI: BLASTP Hits

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Query: NC_011498:1571840:1574353 Helicobacter pylori P12, complete genome

Start: 1574353, End: 1574847, Length: 495

Host Lineage: Helicobacter pylori; Helicobacter; Helicobacteraceae; Campylobacterales; Proteobacteria; Bacteria

General Information: Helicobacter pylori P12 is a clinical isolate obtained from a patient with duodenal ulcer. This genus consists of organisms that colonize the mucosal layer of the gastrointestinal tract or are found enterohepatically (in the liver). It was only recently discovered (1983) by two Australians (Warren and Marshall) that this organism was associated with peptic ulcers. It is one of the most common chronic infectious organisms, and is found in half the world's population. This organism attacks the gastric epithilial surface, resulting in chronic gastritis, and can cause more severe diseases including those that lead to gastric carcinomas and lymphomas, peptic ulcers, and severe diarrhea. It is an extracellular pathogen that persists in the gastric environment, which has a very low pH, by production of the urease enzyme, which converts urea to ammonia and carbon dioxide, a process which can counteract the acidic environment by production of a base. The toxins include cytolethal distending toxin, vacuolating cytotoxin (VacA) that induces host epithelial cell apopoptosis (cell death), and the cytotoxin associated antigen (CagA) which results in alteration to the host cell signalling pathways. The CagA protein is translocated into host cells by a type IV secretion system encoded by the cag pathogenicity island.




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SubjectStartEndLengthSubject Host DescriptionCDS descriptionE-valueBit score
NC_014560:1366747:137349813734981374181684Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein3e-73273
NC_000921:1007519:105520210552021055885684Helicobacter pylori J99, complete genomehypothetical protein1e-63241
NC_017371:1470582:148038414803841481064681Helicobacter pylori Gambia94/24 chromosome, complete genomehypothetical protein2e-63241
NC_014256:485969:495875495875496555681Helicobacter pylori B8 chromosome, complete genomehypothetical protein3e-63240
NC_011498:448000:453578453578454261684Helicobacter pylori P12, complete genomehypothetical protein5e-61233
NC_014560:1366747:140620314062031406886684Helicobacter pylori SJM180 chromosome, complete genomehypothetical protein3e-60230
NC_017063:834674:877527877527877967441Helicobacter pylori ELS37 chromosome, complete genomehypothetical protein9e-54209
NC_014256:485969:526917526917527504588Helicobacter pylori B8 chromosome, complete genomehypothetical protein1e-52205
NC_014555:1526775:153640915364091536792384Helicobacter pylori PeCan4 chromosome, complete genomehypothetical protein2e-1891.7